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Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

Genomic DNA in eukaryotes is organized into chromatin through association with core histones to form nucleosomes, each distinguished by their DNA sequences and histone variants. Here, we used a single-chain antibody fragment (scFv) derived from the anti-nucleosome antibody mAb PL2-6 to stabilize hum...

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Detalles Bibliográficos
Autores principales:	Zhou, Bing-Rui, Yadav, K. N. Sathish, Borgnia, Mario, Hong, Jingjun, Cao, Baohua, Olins, Ada L., Olins, Donald E., Bai, Yawen, Zhang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534667/ https://www.ncbi.nlm.nih.gov/pubmed/31127102 http://dx.doi.org/10.1038/s41467-019-10247-4

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