One reference genome is not enough

A recent study on human structural variation indicates insufficiencies and errors in the human reference genome, GRCh38, and argues for the construction of a human pan-genome.

Detalles Bibliográficos
Autores principales: Yang, Xiaofei, Lee, Wan-Ping, Ye, Kai, Lee, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534916/
https://www.ncbi.nlm.nih.gov/pubmed/31126314
http://dx.doi.org/10.1186/s13059-019-1717-0
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author Yang, Xiaofei
Lee, Wan-Ping
Ye, Kai
Lee, Charles
author_facet Yang, Xiaofei
Lee, Wan-Ping
Ye, Kai
Lee, Charles
author_sort Yang, Xiaofei
collection PubMed
description A recent study on human structural variation indicates insufficiencies and errors in the human reference genome, GRCh38, and argues for the construction of a human pan-genome.
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spelling pubmed-65349162019-05-30 One reference genome is not enough Yang, Xiaofei Lee, Wan-Ping Ye, Kai Lee, Charles Genome Biol Research Highlight A recent study on human structural variation indicates insufficiencies and errors in the human reference genome, GRCh38, and argues for the construction of a human pan-genome. BioMed Central 2019-05-24 /pmc/articles/PMC6534916/ /pubmed/31126314 http://dx.doi.org/10.1186/s13059-019-1717-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Yang, Xiaofei
Lee, Wan-Ping
Ye, Kai
Lee, Charles
One reference genome is not enough
title One reference genome is not enough
title_full One reference genome is not enough
title_fullStr One reference genome is not enough
title_full_unstemmed One reference genome is not enough
title_short One reference genome is not enough
title_sort one reference genome is not enough
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534916/
https://www.ncbi.nlm.nih.gov/pubmed/31126314
http://dx.doi.org/10.1186/s13059-019-1717-0
work_keys_str_mv AT yangxiaofei onereferencegenomeisnotenough
AT leewanping onereferencegenomeisnotenough
AT yekai onereferencegenomeisnotenough
AT leecharles onereferencegenomeisnotenough

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