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Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 yea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534928/ https://www.ncbi.nlm.nih.gov/pubmed/31149031 http://dx.doi.org/10.1186/s13098-019-0435-9 |
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author | Sparrenberger, Karen Sbaraini, Mariana Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Schaan, Beatriz D. |
author_facet | Sparrenberger, Karen Sbaraini, Mariana Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Schaan, Beatriz D. |
author_sort | Sparrenberger, Karen |
collection | PubMed |
description | OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. RESULTS: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. CONCLUSION: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0435-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6534928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65349282019-05-30 Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents Sparrenberger, Karen Sbaraini, Mariana Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Schaan, Beatriz D. Diabetol Metab Syndr Research OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. RESULTS: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. CONCLUSION: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0435-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-24 /pmc/articles/PMC6534928/ /pubmed/31149031 http://dx.doi.org/10.1186/s13098-019-0435-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Sparrenberger, Karen Sbaraini, Mariana Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Schaan, Beatriz D. Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title | Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_full | Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_fullStr | Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_full_unstemmed | Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_short | Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents |
title_sort | higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in brazilian adolescents |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534928/ https://www.ncbi.nlm.nih.gov/pubmed/31149031 http://dx.doi.org/10.1186/s13098-019-0435-9 |
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