Cargando…

Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 yea...

Descripción completa

Detalles Bibliográficos
Autores principales: Sparrenberger, Karen, Sbaraini, Mariana, Cureau, Felipe Vogt, Teló, Gabriela Heiden, Bahia, Luciana, Schaan, Beatriz D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534928/
https://www.ncbi.nlm.nih.gov/pubmed/31149031
http://dx.doi.org/10.1186/s13098-019-0435-9
_version_ 1783421512467873792
author Sparrenberger, Karen
Sbaraini, Mariana
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana
Schaan, Beatriz D.
author_facet Sparrenberger, Karen
Sbaraini, Mariana
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana
Schaan, Beatriz D.
author_sort Sparrenberger, Karen
collection PubMed
description OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. RESULTS: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. CONCLUSION: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0435-9) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6534928
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-65349282019-05-30 Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents Sparrenberger, Karen Sbaraini, Mariana Cureau, Felipe Vogt Teló, Gabriela Heiden Bahia, Luciana Schaan, Beatriz D. Diabetol Metab Syndr Research OBJECTIVE: To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. METHODS: Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. RESULTS: Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. CONCLUSION: Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0435-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-24 /pmc/articles/PMC6534928/ /pubmed/31149031 http://dx.doi.org/10.1186/s13098-019-0435-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sparrenberger, Karen
Sbaraini, Mariana
Cureau, Felipe Vogt
Teló, Gabriela Heiden
Bahia, Luciana
Schaan, Beatriz D.
Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_full Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_fullStr Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_full_unstemmed Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_short Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents
title_sort higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in brazilian adolescents
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534928/
https://www.ncbi.nlm.nih.gov/pubmed/31149031
http://dx.doi.org/10.1186/s13098-019-0435-9
work_keys_str_mv AT sparrenbergerkaren higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents
AT sbarainimariana higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents
AT cureaufelipevogt higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents
AT telogabrielaheiden higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents
AT bahialuciana higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents
AT schaanbeatrizd higheradiponectinconcentrationsareassociatedwithreducedmetabolicsyndromeriskindependentlyofweightstatusinbrazilianadolescents