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Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players

BACKGROUND: Immunological alterations may led to the reduction in capacity and endurance levels in elite athletes by e.g. increased susceptibility to infections. There is a need to explain the impact of intensive physical effort on the CD4(+) memory T cell subsets. METHODS: Fourteen participants med...

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Autores principales: Kostrzewa-Nowak, Dorota, Buryta, Rafał, Nowak, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534948/
https://www.ncbi.nlm.nih.gov/pubmed/31156335
http://dx.doi.org/10.2478/jomb-2018-0029
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author Kostrzewa-Nowak, Dorota
Buryta, Rafał
Nowak, Robert
author_facet Kostrzewa-Nowak, Dorota
Buryta, Rafał
Nowak, Robert
author_sort Kostrzewa-Nowak, Dorota
collection PubMed
description BACKGROUND: Immunological alterations may led to the reduction in capacity and endurance levels in elite athletes by e.g. increased susceptibility to infections. There is a need to explain the impact of intensive physical effort on the CD4(+) memory T cell subsets. METHODS: Fourteen participants median aged 19 years old (range 17–21 years) were recruited form Pogoń Szczecin S.A., soccer club. They performed progressive efficiency test on mechanical treadmill until exhaustion twice: during preparatory phases to spring and autumn competition rounds. We examined the influence of exhaustive effort on the selected CD45(+), especially CD4(+) memory T cell subsets and inflammation markers determined before, just after the test and during recovery time. RESULTS: Significant changes in total CD45(+) cells and decrease in T lymphocytes percentage after the run was observed. Significant fluctuations in T cells’ distribution were related not only to the changes in Th or Tc subsets but also to increase in naïve T cell percentage during recovery. Increase in TNF-α and IL-8 post-exercise, IL-6 and IL-10 plasma levels in recovery was also found. CONCLUSIONS: The novel finding of our study is that the run performed on mechanical treadmill caused a significant release of CD4(+) T naïve cells into circulation. Post-exercise increase in circulating NK cells is related with fast biological response to maximal effort. However, at the same time an alternative mechanism enhancing inflammation is involved.
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spelling pubmed-65349482019-05-31 Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players Kostrzewa-Nowak, Dorota Buryta, Rafał Nowak, Robert J Med Biochem Original Paper BACKGROUND: Immunological alterations may led to the reduction in capacity and endurance levels in elite athletes by e.g. increased susceptibility to infections. There is a need to explain the impact of intensive physical effort on the CD4(+) memory T cell subsets. METHODS: Fourteen participants median aged 19 years old (range 17–21 years) were recruited form Pogoń Szczecin S.A., soccer club. They performed progressive efficiency test on mechanical treadmill until exhaustion twice: during preparatory phases to spring and autumn competition rounds. We examined the influence of exhaustive effort on the selected CD45(+), especially CD4(+) memory T cell subsets and inflammation markers determined before, just after the test and during recovery time. RESULTS: Significant changes in total CD45(+) cells and decrease in T lymphocytes percentage after the run was observed. Significant fluctuations in T cells’ distribution were related not only to the changes in Th or Tc subsets but also to increase in naïve T cell percentage during recovery. Increase in TNF-α and IL-8 post-exercise, IL-6 and IL-10 plasma levels in recovery was also found. CONCLUSIONS: The novel finding of our study is that the run performed on mechanical treadmill caused a significant release of CD4(+) T naïve cells into circulation. Post-exercise increase in circulating NK cells is related with fast biological response to maximal effort. However, at the same time an alternative mechanism enhancing inflammation is involved. Sciendo 2019-05-11 /pmc/articles/PMC6534948/ /pubmed/31156335 http://dx.doi.org/10.2478/jomb-2018-0029 Text en © 2019 Dorota Kostrzewa-Nowak, Rafał Buryta, Robert Nowak, published by sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Original Paper
Kostrzewa-Nowak, Dorota
Buryta, Rafał
Nowak, Robert
Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title_full Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title_fullStr Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title_full_unstemmed Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title_short Comparison of Selected CD45(+) Cell Subsets’ Response and Cytokine Levels on Exhaustive Effort Among Soccer Players
title_sort comparison of selected cd45(+) cell subsets’ response and cytokine levels on exhaustive effort among soccer players
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534948/
https://www.ncbi.nlm.nih.gov/pubmed/31156335
http://dx.doi.org/10.2478/jomb-2018-0029
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