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TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure

BACKGROUND: Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers i...

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Autores principales: Tutkun, Lütfiye, İritaş, Servet Birgin, Deniz, Serdar, Öztan, Özgür, Abuşoğlu, Sedat, Ünlü, Ali, Türksoy, Vugar Ali, Çetintepe, Sultan Pınar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534953/
https://www.ncbi.nlm.nih.gov/pubmed/31156337
http://dx.doi.org/10.2478/jomb-2018-0040
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author Tutkun, Lütfiye
İritaş, Servet Birgin
Deniz, Serdar
Öztan, Özgür
Abuşoğlu, Sedat
Ünlü, Ali
Türksoy, Vugar Ali
Çetintepe, Sultan Pınar
author_facet Tutkun, Lütfiye
İritaş, Servet Birgin
Deniz, Serdar
Öztan, Özgür
Abuşoğlu, Sedat
Ünlü, Ali
Türksoy, Vugar Ali
Çetintepe, Sultan Pınar
author_sort Tutkun, Lütfiye
collection PubMed
description BACKGROUND: Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. METHODS: 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. RESULTS: When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). CONCLUSIONS: In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure.
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spelling pubmed-65349532019-05-31 TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure Tutkun, Lütfiye İritaş, Servet Birgin Deniz, Serdar Öztan, Özgür Abuşoğlu, Sedat Ünlü, Ali Türksoy, Vugar Ali Çetintepe, Sultan Pınar J Med Biochem Original Paper BACKGROUND: Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. METHODS: 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. RESULTS: When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). CONCLUSIONS: In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure. Sciendo 2019-05-11 /pmc/articles/PMC6534953/ /pubmed/31156337 http://dx.doi.org/10.2478/jomb-2018-0040 Text en © 2019 Lütfiye Tutkun, Servet Birgin İritaş, Serdar Deniz, Özgür Öztan, Sedat Abuşoğlu, Ali Ünlü, Vugar Ali Türksoy, Sultan Pınar Çetintepe, published by sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Original Paper
Tutkun, Lütfiye
İritaş, Servet Birgin
Deniz, Serdar
Öztan, Özgür
Abuşoğlu, Sedat
Ünlü, Ali
Türksoy, Vugar Ali
Çetintepe, Sultan Pınar
TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title_full TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title_fullStr TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title_full_unstemmed TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title_short TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure
title_sort tnf-α and il-6 as biomarkers of impaired lung functions in dimethylacetamide exposure
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534953/
https://www.ncbi.nlm.nih.gov/pubmed/31156337
http://dx.doi.org/10.2478/jomb-2018-0040
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