Exploring Sirolimus Pharmacokinetic Variability Using Data Available from the Routine Clinical Care of Renal Transplant Patients – Population Pharmacokinetic Approach

BACKGROUND: Due to wide intra- and inter-individual pharmacokinetic variability and narrow therapeutic index of sirolimus, the therapeutic drug monitoring (TDM) of sirolimus with detailed biochemical and clinical monitoring is necessary for dose individualization in kidney transplant patients. The p...

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Detalles Bibliográficos
Autores principales: Golubović, Bojana, Vučićević, Katarina, Radivojević, Dragana, Kovačević, Sandra Vezmar, Prostran, Milica, Miljković, Branislava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534959/
https://www.ncbi.nlm.nih.gov/pubmed/31156343
http://dx.doi.org/10.2478/jomb-2018-0030

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