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Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study

Background: Temporary hypocalcemia is the most common complication in patients after total thyroidectomy. To date, according to the literature, various predictors of the above complication have been proposed, but none of them seems to be effective enough. Objectives: The aim of this study was to dev...

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Autores principales: Papanastasiou, Anastasios, Sapalidis, Konstantinos, Mantalobas, Stylianos, Atmatzidis, Stefanos, Michalopoulos, Nikolaos, Surlin, Valeriu, Katsaounis, Athanasios, Amaniti, Aikaterini, Zarogoulidis, Paul, Passos, Ioannis, Koulouris, Charilaos, Pavlidis, Efstathios, Giannakidis, Dimitrios, Mogoanta, Stelian, Kosmidis, Christoforos, Kesisoglou, Isaak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535084/
https://www.ncbi.nlm.nih.gov/pubmed/31190953
http://dx.doi.org/10.2147/IJGM.S204795
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author Papanastasiou, Anastasios
Sapalidis, Konstantinos
Mantalobas, Stylianos
Atmatzidis, Stefanos
Michalopoulos, Nikolaos
Surlin, Valeriu
Katsaounis, Athanasios
Amaniti, Aikaterini
Zarogoulidis, Paul
Passos, Ioannis
Koulouris, Charilaos
Pavlidis, Efstathios
Giannakidis, Dimitrios
Mogoanta, Stelian
Kosmidis, Christoforos
Kesisoglou, Isaak
author_facet Papanastasiou, Anastasios
Sapalidis, Konstantinos
Mantalobas, Stylianos
Atmatzidis, Stefanos
Michalopoulos, Nikolaos
Surlin, Valeriu
Katsaounis, Athanasios
Amaniti, Aikaterini
Zarogoulidis, Paul
Passos, Ioannis
Koulouris, Charilaos
Pavlidis, Efstathios
Giannakidis, Dimitrios
Mogoanta, Stelian
Kosmidis, Christoforos
Kesisoglou, Isaak
author_sort Papanastasiou, Anastasios
collection PubMed
description Background: Temporary hypocalcemia is the most common complication in patients after total thyroidectomy. To date, according to the literature, various predictors of the above complication have been proposed, but none of them seems to be effective enough. Objectives: The aim of this study was to develop a reliable predictive tool for biochemical hypocalcemia in the first 48 hrs after total thyroidectomy without central dissection by analyzing several parameters relevant to this operation and to suggest a new score. Methods: A retrospective study was performed on patients who had undergone total thyroidectomy without central neck dissection from October 2017 until January 2018. Data were collected from 36 patients and studied if there was a statistically significant relationship between the risk of hypocalcemia and 10 preselected prognostic factors. Results: The prognostic score was formed, which included the 6 factors that showed a statistically significant relationship. Moreover, an extensive check of the predictive value of the above score was performed. It was found, therefore, that at a value of 3 and above the sensitivity was 100%, the specificity 79.16%, the positive prognostic value (PPV) 70.58% and the negative predictive value (NPV) 100%. Conclusions: High sensitivity of CaReBe’S TiP score makes it feasible to predict patients with postoperative hypocalcemia. High NPV would allow surgeons to exclude patients with a score less than 3 from supplementary calcium medication and achieve a shorter hospitalization for them.
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spelling pubmed-65350842019-06-12 Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study Papanastasiou, Anastasios Sapalidis, Konstantinos Mantalobas, Stylianos Atmatzidis, Stefanos Michalopoulos, Nikolaos Surlin, Valeriu Katsaounis, Athanasios Amaniti, Aikaterini Zarogoulidis, Paul Passos, Ioannis Koulouris, Charilaos Pavlidis, Efstathios Giannakidis, Dimitrios Mogoanta, Stelian Kosmidis, Christoforos Kesisoglou, Isaak Int J Gen Med Original Research Background: Temporary hypocalcemia is the most common complication in patients after total thyroidectomy. To date, according to the literature, various predictors of the above complication have been proposed, but none of them seems to be effective enough. Objectives: The aim of this study was to develop a reliable predictive tool for biochemical hypocalcemia in the first 48 hrs after total thyroidectomy without central dissection by analyzing several parameters relevant to this operation and to suggest a new score. Methods: A retrospective study was performed on patients who had undergone total thyroidectomy without central neck dissection from October 2017 until January 2018. Data were collected from 36 patients and studied if there was a statistically significant relationship between the risk of hypocalcemia and 10 preselected prognostic factors. Results: The prognostic score was formed, which included the 6 factors that showed a statistically significant relationship. Moreover, an extensive check of the predictive value of the above score was performed. It was found, therefore, that at a value of 3 and above the sensitivity was 100%, the specificity 79.16%, the positive prognostic value (PPV) 70.58% and the negative predictive value (NPV) 100%. Conclusions: High sensitivity of CaReBe’S TiP score makes it feasible to predict patients with postoperative hypocalcemia. High NPV would allow surgeons to exclude patients with a score less than 3 from supplementary calcium medication and achieve a shorter hospitalization for them. Dove 2019-05-20 /pmc/articles/PMC6535084/ /pubmed/31190953 http://dx.doi.org/10.2147/IJGM.S204795 Text en © 2019 Papanastasiou et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Papanastasiou, Anastasios
Sapalidis, Konstantinos
Mantalobas, Stylianos
Atmatzidis, Stefanos
Michalopoulos, Nikolaos
Surlin, Valeriu
Katsaounis, Athanasios
Amaniti, Aikaterini
Zarogoulidis, Paul
Passos, Ioannis
Koulouris, Charilaos
Pavlidis, Efstathios
Giannakidis, Dimitrios
Mogoanta, Stelian
Kosmidis, Christoforos
Kesisoglou, Isaak
Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title_full Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title_fullStr Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title_full_unstemmed Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title_short Design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. A retrospective study
title_sort design of a predictive score to assess the risk of developing hypocalcemia after total thyroidectomy. a retrospective study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535084/
https://www.ncbi.nlm.nih.gov/pubmed/31190953
http://dx.doi.org/10.2147/IJGM.S204795
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