Cargando…
Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products
Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on tw...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535546/ https://www.ncbi.nlm.nih.gov/pubmed/30910900 http://dx.doi.org/10.1128/AAC.02338-18 |
| _version_ | 1783421582470807552 |
|---|---|
| author | Brouwer, Michael S. M. Tehrani, Kamaleddin H. M. E. Rapallini, Michel Geurts, Yvon Kant, Arie Harders, Frank Mashayekhi, Vida Martin, Nathaniel I. Bossers, Alex Mevius, Dik J. Wit, Ben Veldman, Kees T. |
| author_facet | Brouwer, Michael S. M. Tehrani, Kamaleddin H. M. E. Rapallini, Michel Geurts, Yvon Kant, Arie Harders, Frank Mashayekhi, Vida Martin, Nathaniel I. Bossers, Alex Mevius, Dik J. Wit, Ben Veldman, Kees T. |
| author_sort | Brouwer, Michael S. M. |
| collection | PubMed |
| description | Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined. |
| format | Online Article Text |
| id | pubmed-6535546 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65355462019-06-03 Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products Brouwer, Michael S. M. Tehrani, Kamaleddin H. M. E. Rapallini, Michel Geurts, Yvon Kant, Arie Harders, Frank Mashayekhi, Vida Martin, Nathaniel I. Bossers, Alex Mevius, Dik J. Wit, Ben Veldman, Kees T. Antimicrob Agents Chemother Mechanisms of Resistance Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined. American Society for Microbiology 2019-05-23 /pmc/articles/PMC6535546/ /pubmed/30910900 http://dx.doi.org/10.1128/AAC.02338-18 Text en Copyright © 2019 Brouwer et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Mechanisms of Resistance Brouwer, Michael S. M. Tehrani, Kamaleddin H. M. E. Rapallini, Michel Geurts, Yvon Kant, Arie Harders, Frank Mashayekhi, Vida Martin, Nathaniel I. Bossers, Alex Mevius, Dik J. Wit, Ben Veldman, Kees T. Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title | Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title_full | Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title_fullStr | Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title_full_unstemmed | Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title_short | Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products |
| title_sort | novel carbapenemases flc-1 and imi-2 encoded by an enterobacter cloacae complex isolated from food products |
| topic | Mechanisms of Resistance |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535546/ https://www.ncbi.nlm.nih.gov/pubmed/30910900 http://dx.doi.org/10.1128/AAC.02338-18 |
| work_keys_str_mv | AT brouwermichaelsm novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT tehranikamaleddinhme novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT rapallinimichel novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT geurtsyvon novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT kantarie novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT hardersfrank novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT mashayekhivida novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT martinnathanieli novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT bossersalex novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT meviusdikj novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT witben novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts AT veldmankeest novelcarbapenemasesflc1andimi2encodedbyanenterobactercloacaecomplexisolatedfromfoodproducts |