Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment

Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data suppor...

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Autores principales: Cai, Fengfeng, Luis, Manuel Antonio Falar, Lin, Xiaoyan, Wang, Minghong, Cai, Lu, Cen, Chunmei, Biskup, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535635/
https://www.ncbi.nlm.nih.gov/pubmed/31289672
http://dx.doi.org/10.3892/mco.2019.1854
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author Cai, Fengfeng
Luis, Manuel Antonio Falar
Lin, Xiaoyan
Wang, Minghong
Cai, Lu
Cen, Chunmei
Biskup, Ewelina
author_facet Cai, Fengfeng
Luis, Manuel Antonio Falar
Lin, Xiaoyan
Wang, Minghong
Cai, Lu
Cen, Chunmei
Biskup, Ewelina
author_sort Cai, Fengfeng
collection PubMed
description Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline-induced cardiotoxicity. The objective of this paper was to provide a review of the clinical classification, risk factors, monitoring and prevention of anthracycline-induced cardiotoxicity in patients with breast cancer.
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spelling pubmed-65356352019-07-09 Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment Cai, Fengfeng Luis, Manuel Antonio Falar Lin, Xiaoyan Wang, Minghong Cai, Lu Cen, Chunmei Biskup, Ewelina Mol Clin Oncol Review Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline-induced cardiotoxicity. The objective of this paper was to provide a review of the clinical classification, risk factors, monitoring and prevention of anthracycline-induced cardiotoxicity in patients with breast cancer. D.A. Spandidos 2019-07 2019-05-08 /pmc/articles/PMC6535635/ /pubmed/31289672 http://dx.doi.org/10.3892/mco.2019.1854 Text en Copyright: © Cai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Cai, Fengfeng
Luis, Manuel Antonio Falar
Lin, Xiaoyan
Wang, Minghong
Cai, Lu
Cen, Chunmei
Biskup, Ewelina
Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title_full Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title_fullStr Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title_full_unstemmed Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title_short Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment
title_sort anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: preventive strategies and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535635/
https://www.ncbi.nlm.nih.gov/pubmed/31289672
http://dx.doi.org/10.3892/mco.2019.1854
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