adeABC efflux gene in Acinetobacter baumannii

The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues to grow; it has become a global health issue, particularly in regards to carbapenem resistance. The expression of efflux pumps is one of the major mechanisms of antibiotic resistance in A. baumannii by, most...

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Detalles Bibliográficos
Autores principales: Xu, C., Bilya, S.R., Xu, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535689/
https://www.ncbi.nlm.nih.gov/pubmed/31193498
http://dx.doi.org/10.1016/j.nmni.2019.100549
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author Xu, C.
Bilya, S.R.
Xu, W.
author_facet Xu, C.
Bilya, S.R.
Xu, W.
author_sort Xu, C.
collection PubMed
description The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues to grow; it has become a global health issue, particularly in regards to carbapenem resistance. The expression of efflux pumps is one of the major mechanisms of antibiotic resistance in A. baumannii by, most prevalently, adeABC of the resistance/nodulation/division family. The detection rate of adeB was the highest in clinical isolates compared to others (adeFGH, adeIJk), although it varied among other strains. In this minireview, we explain the adeABC efflux gene in A. baumannii causing antibiotic resistance and compare adeABC with other efflux genes in order to discern the function of adeABC in A. baumannii resistance, which may help in the discovery of new antibacterial agents.
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spelling pubmed-65356892019-05-30 adeABC efflux gene in Acinetobacter baumannii Xu, C. Bilya, S.R. Xu, W. New Microbes New Infect Mini-Review The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues to grow; it has become a global health issue, particularly in regards to carbapenem resistance. The expression of efflux pumps is one of the major mechanisms of antibiotic resistance in A. baumannii by, most prevalently, adeABC of the resistance/nodulation/division family. The detection rate of adeB was the highest in clinical isolates compared to others (adeFGH, adeIJk), although it varied among other strains. In this minireview, we explain the adeABC efflux gene in A. baumannii causing antibiotic resistance and compare adeABC with other efflux genes in order to discern the function of adeABC in A. baumannii resistance, which may help in the discovery of new antibacterial agents. Elsevier 2019-04-10 /pmc/articles/PMC6535689/ /pubmed/31193498 http://dx.doi.org/10.1016/j.nmni.2019.100549 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Review
Xu, C.
Bilya, S.R.
Xu, W.
adeABC efflux gene in Acinetobacter baumannii
title adeABC efflux gene in Acinetobacter baumannii
title_full adeABC efflux gene in Acinetobacter baumannii
title_fullStr adeABC efflux gene in Acinetobacter baumannii
title_full_unstemmed adeABC efflux gene in Acinetobacter baumannii
title_short adeABC efflux gene in Acinetobacter baumannii
title_sort adeabc efflux gene in acinetobacter baumannii
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535689/
https://www.ncbi.nlm.nih.gov/pubmed/31193498
http://dx.doi.org/10.1016/j.nmni.2019.100549
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