Cargando…

Small Molecule Inhibitors of the BfrB–Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity

[Image: see text] The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Punchi Hewage, Achala N. D., Yao, Huili, Nammalwar, Baskar, Gnanasekaran, Krishna Kumar, Lovell, Scott, Bunce, Richard A., Eshelman, Kate, Phaniraj, Sahishna M., Lee, Molly M., Peterson, Blake R., Battaile, Kevin P., Reitz, Allen B., Rivera, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535718/ https://www.ncbi.nlm.nih.gov/pubmed/31038945 http://dx.doi.org/10.1021/jacs.9b00394

Ejemplares similares

Small Molecule Inhibitors of the Bacterioferritin (BfrB)–Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells
por: Soldano, Anabel, et al.
Publicado: (2020)

Pseudomonas aeruginosa Bacterioferritin Is Assembled from FtnA and BfrB Subunits with the Relative Proportions Dependent on the Environmental Oxygen Availability
por: Yao, Huili, et al.
Publicado: (2022)

Recent Syntheses of 1,2,3,4-Tetrahydroquinolines, 2,3-Dihydro-4(1H)-quinolinones and 4(1H)-Quinolinones using Domino Reactions
por: Nammalwar, Baskar, et al.
Publicado: (2013)

OSU-6: A Highly Efficient, Metal-Free, Heterogeneous Catalyst for the Click Synthesis of 5-Benzyl and 5-Aryl-1H-tetrazoles
por: Nammalwar, Baskar, et al.
Publicado: (2015)

Mobilization of Iron Stored in Bacterioferritin Is Required for Metabolic Homeostasis in Pseudomonas aeruginosa
por: Punchi Hewage, Achala N. D., et al.
Publicado: (2020)

Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks
por: Ghazikhani, Hamed, et al.
Publicado: (2023)

The EU chemicals strategy for sustainability: in support of the BfR position
por: Barile, Frank A., et al.
Publicado: (2021)

Statement on the BfR opinion regarding the toxicity of 2‐chloroethanol
por: Borroto, Jorge, et al.
Publicado: (2022)

Evaluation of Common Use Brominated Flame Retardant (BFR) Toxicity Using a Zebrafish Embryo Model
por: Usenko, Crystal Y., et al.
Publicado: (2016)

Complete Genome Sequence of a Bacteroides fragilis Bacteriophage, vB_BfrS_NCTC
por: Tariq, Mohammad A., et al.
Publicado: (2021)

SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres
por: Benbrook, Doris Mangiaracina, et al.
Publicado: (2013)

Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial
por: Blesius, Aurore, et al.
Publicado: (2011)

Vaccination with recombinant Toxoplasma gondii bradyzoite-formation deficient 1 (rTgBFD1) antigen provides partial protective immunity against chronic T. gondii infection
por: Tian, Xiaowei, et al.
Publicado: (2022)

The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking
por: Bourne, Christina R., et al.
Publicado: (2014)

Crystal Structure of Bfr A from Mycobacterium tuberculosis: Incorporation of Selenomethionine Results in Cleavage and Demetallation of Haem
por: Gupta, Vibha, et al.
Publicado: (2009)

Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation
por: Castells-Ballester, Joan, et al.
Publicado: (2019)

Comparison of different technologies for the decipherment of the whole genome sequence of Campylobacter jejuni BfR-CA-14430
por: Epping, Lennard, et al.
Publicado: (2019)

Characterization of a Bacteriophage GEC_vB_Bfr_UZM3 Active against Bacteroides fragilis
por: Bakuradze, Nata, et al.
Publicado: (2023)

SMRT sequencing of the Campylobacter coli BfR-CA-9557 genome sequence reveals unique methylation motifs
por: Zautner, Andreas E., et al.
Publicado: (2015)

Effects of blood flow restriction (BFR) with resistance exercise on musculoskeletal health in older adults: a narrative review
por: Lim, Zi Xiang, et al.
Publicado: (2022)

Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein–Protein Interaction in Solution and Determination of Binding Energy Hot Spots
por: Wang, Yan, et al.
Publicado: (2015)

Collection of occurrence data in foods – The value of the BfR MEAL study in addition to the national monitoring for dietary exposure assessment
por: Kolbaum, Anna Elena, et al.
Publicado: (2022)

mRNA localization to Pbodies in yeast is biphasic with many mRNAs captured in a late Bfr1pdependent wave
por: Simpson, Clare E., et al.
Publicado: (2014)

Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes
por: Soltanieh, Sahar, et al.
Publicado: (2014)

Genome Characterization of a Novel Wastewater Bacteroides fragilis Bacteriophage (vB_BfrS_23) and its Host GB124
por: Tariq, Mohammad A., et al.
Publicado: (2020)

Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1
por: Manchalu, Srinivas, et al.
Publicado: (2019)

Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome
por: Zhao, Yu, et al.
Publicado: (2022)

Experimental Study on the Mechanical Behaviors of Aeolian Sand Treated by Microbially Induced Calcite Precipitation (MICP) and Basalt Fiber Reinforcement (BFR)
por: Liu, Jia, et al.
Publicado: (2023)

Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex
por: Muddala, Nagendra Prasad, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of 2,4-Diaminopyrimidine-Based Antifolate Drugs against Bacillus anthracis
por: Nammalwar, Baskar, et al.
Publicado: (2014)

Replacing the Axial Ligand Tyrosine 75 or Its Hydrogen Bond Partner Histidine 83 Minimally Affects Hemin Acquisition by the Hemophore HasAp from Pseudomonas aeruginosa
por: Kumar, Ritesh, et al.
Publicado: (2014)

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects: Current knowledge assembled at an international workshop at BfR, Germany
por: Peiser, M., et al.
Publicado: (2011)

State of the art in human risk assessment of silver compounds in consumer products: a conference report on silver and nanosilver held at the BfR in 2012
por: Schäfer, Bernd, et al.
Publicado: (2013)

Results of the BfR MEAL Study: Highest levels of retinol found in animal livers and of β-carotene in yellow-orange and green leafy vegetables
por: Schendel, Sophia, et al.
Publicado: (2022)

Pseudomonas aeruginosa Dps (PA0962) Functions in H(2)O(2) Mediated Oxidative Stress Defense and Exhibits In Vitro DNA Cleaving Activity
por: Rajapaksha, Nimesha, et al.
Publicado: (2023)

Etymologia: Fluoroquinolone
por: Henry, Ronne
Publicado: (2017)

High fluoroquinolone MIC is associated with fluoroquinolone treatment failure in urinary tract infections caused by fluoroquinolone susceptible Escherichia coli
por: Rattanaumpawan, Pinyo, et al.
Publicado: (2017)

Synthetic Lethality of the bfr and mbfA Genes Reveals a Functional Relationship between Iron Storage and Iron Export in Managing Stress Responses in Bradyrhizobium japonicum
por: Sankari, Siva, et al.
Publicado: (2016)

Results of the BfR MEAL Study: In Germany, mercury is mostly contained in fish and seafood while cadmium, lead, and nickel are present in a broad spectrum of foods
por: Fechner, Carolin, et al.
Publicado: (2022)

The first German total diet study (BfR MEAL Study) confirms highest levels of dioxins and dioxin-like polychlorinated biphenyls in foods of animal origin
por: Stadion, Mandy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n4i9fgogoev51aa009fcqa5rie