Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer

The mTORC1 inhibitors, such as rapamycin and its analogs, show limited antitumor activity in clinic, reasons for which have not been clearly elucidated. Here, we undertook an effort to uncover the mechanisms underlying the limited efficacy of rapamycin, and found that the transit suppression of 4EBP...

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Detalles Bibliográficos
Autores principales: Wang, Hongtao, Huang, Fang, Zhang, Zhe, Wang, Peng, Luo, Yuan, Li, Hailiang, Li, Na, Wang, Jian, Zhou, Jianguang, Wang, Yongan, Li, Shanhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535796/
https://www.ncbi.nlm.nih.gov/pubmed/31182914
http://dx.doi.org/10.7150/ijbs.32489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535796/
https://www.ncbi.nlm.nih.gov/pubmed/31182914
http://dx.doi.org/10.7150/ijbs.32489

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