Cargando…

Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case

BACKGROUND: Onychomycosis is extremely rare in neonates, infrequently reported in children and is considered to be exclusively a disease of adults. CASE PRESENTATION: We, herein report a case of fingernail onychomycosis in a 28-day-old, healthy, male neonate. The child presented with a history of ye...

Descripción completa

Detalles Bibliográficos
Autores principales: Subramanya, Supram Hosuru, Subedi, Saujan, Metok, Yang, Kumar, Ajay, Prakash, Peralam Yegneswaran, Nayak, Niranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535841/
https://www.ncbi.nlm.nih.gov/pubmed/31133007
http://dx.doi.org/10.1186/s12887-019-1549-9
_version_ 1783421646030241792
author Subramanya, Supram Hosuru
Subedi, Saujan
Metok, Yang
Kumar, Ajay
Prakash, Peralam Yegneswaran
Nayak, Niranjan
author_facet Subramanya, Supram Hosuru
Subedi, Saujan
Metok, Yang
Kumar, Ajay
Prakash, Peralam Yegneswaran
Nayak, Niranjan
author_sort Subramanya, Supram Hosuru
collection PubMed
description BACKGROUND: Onychomycosis is extremely rare in neonates, infrequently reported in children and is considered to be exclusively a disease of adults. CASE PRESENTATION: We, herein report a case of fingernail onychomycosis in a 28-day-old, healthy, male neonate. The child presented with a history of yellowish discoloration of the fingernail of the left hand for one week. The etiological agent was demonstrated both by microscopic examination and culture of nail clippings. The isolate grown on culture was identified as Candida albicans by phenotypic characteristics and by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Antifungal sensitivity testing was performed by broth dilution method as per the Clinical & Laboratory Standards Institute guidelines. An oral swab culture of the child also yielded C. albicans with the same antibiogram as the nail isolate. The case was diagnosed as distal and lateral subungual candida onychomycosis of severity index score 22 (severe) and was treated with syrup fluconazole 6 mg/kg body weight/week and 5% amorolfine nail lacquer once/week for three months. After three months of therapy, the patient completely recovered with the development of a healthy nail plate. CONCLUSIONS: The case is presented due to its rarity in neonates which, we suppose is the first case report of onychomycosis from Nepal in a 28-day-old neonate. Oral colonization with pathogenic yeasts and finger suckling could be risk factors for neonatal onychomycosis.
format Online
Article
Text
id pubmed-6535841
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-65358412019-05-30 Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case Subramanya, Supram Hosuru Subedi, Saujan Metok, Yang Kumar, Ajay Prakash, Peralam Yegneswaran Nayak, Niranjan BMC Pediatr Case Report BACKGROUND: Onychomycosis is extremely rare in neonates, infrequently reported in children and is considered to be exclusively a disease of adults. CASE PRESENTATION: We, herein report a case of fingernail onychomycosis in a 28-day-old, healthy, male neonate. The child presented with a history of yellowish discoloration of the fingernail of the left hand for one week. The etiological agent was demonstrated both by microscopic examination and culture of nail clippings. The isolate grown on culture was identified as Candida albicans by phenotypic characteristics and by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Antifungal sensitivity testing was performed by broth dilution method as per the Clinical & Laboratory Standards Institute guidelines. An oral swab culture of the child also yielded C. albicans with the same antibiogram as the nail isolate. The case was diagnosed as distal and lateral subungual candida onychomycosis of severity index score 22 (severe) and was treated with syrup fluconazole 6 mg/kg body weight/week and 5% amorolfine nail lacquer once/week for three months. After three months of therapy, the patient completely recovered with the development of a healthy nail plate. CONCLUSIONS: The case is presented due to its rarity in neonates which, we suppose is the first case report of onychomycosis from Nepal in a 28-day-old neonate. Oral colonization with pathogenic yeasts and finger suckling could be risk factors for neonatal onychomycosis. BioMed Central 2019-05-27 /pmc/articles/PMC6535841/ /pubmed/31133007 http://dx.doi.org/10.1186/s12887-019-1549-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Subramanya, Supram Hosuru
Subedi, Saujan
Metok, Yang
Kumar, Ajay
Prakash, Peralam Yegneswaran
Nayak, Niranjan
Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title_full Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title_fullStr Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title_full_unstemmed Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title_short Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
title_sort distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535841/
https://www.ncbi.nlm.nih.gov/pubmed/31133007
http://dx.doi.org/10.1186/s12887-019-1549-9
work_keys_str_mv AT subramanyasupramhosuru distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase
AT subedisaujan distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase
AT metokyang distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase
AT kumarajay distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase
AT prakashperalamyegneswaran distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase
AT nayakniranjan distalandlateralsubungualonychomycosisofthefingernailinaneonateararecase