Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1, which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and development. However, precise causal RASGRP1 functional varia...

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Detalles Bibliográficos
Autores principales: Molineros, Julio E., Singh, Bhupinder, Terao, Chikashi, Okada, Yukinori, Kaplan, Jakub, McDaniel, Barbara, Akizuki, Shuji, Sun, Celi, Webb, Carol F., Looger, Loren L., Nath, Swapan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536009/
https://www.ncbi.nlm.nih.gov/pubmed/31164884
http://dx.doi.org/10.3389/fimmu.2019.01066

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