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Bilateral liver metastases from testicular sex cord-stromal tumour
A 28-year-old man previously diagnosed and treated for testicular sex cord-stromal tumour (TSCST) presented with symptoms of fever, night sweats and fatigue. Following initial investigations for an infectious aetiology, imaging studies detected two large liver lesions. Histopathological assessment o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536236/ https://www.ncbi.nlm.nih.gov/pubmed/31122957 http://dx.doi.org/10.1136/bcr-2018-228857 |
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author | Palmieri, Vincent Al-Mahmeed, Husain Metrakos, Peter |
author_facet | Palmieri, Vincent Al-Mahmeed, Husain Metrakos, Peter |
author_sort | Palmieri, Vincent |
collection | PubMed |
description | A 28-year-old man previously diagnosed and treated for testicular sex cord-stromal tumour (TSCST) presented with symptoms of fever, night sweats and fatigue. Following initial investigations for an infectious aetiology, imaging studies detected two large liver lesions. Histopathological assessment of the tumours revealed that they were metastases from the TSCST for which the patient had radical inguinal orchiectomy and retroperitoneal lymph node dissection 5 years prior. The curative-intent management of the bilobar liver metastases necessitated staged resection due to the chemoresistant and radioresistant properties of TSCST. The size of the lesions was such that procedures to induce rapid liver hypertrophy were required between surgeries. Both liver metastases were successfully removed following this approach. The patient remains recurrence-free 1 year after surgery and has maintained predisease levels of performance. Nevertheless, he continues to be followed for routine CT scans at regular intervals. |
format | Online Article Text |
id | pubmed-6536236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-65362362019-06-12 Bilateral liver metastases from testicular sex cord-stromal tumour Palmieri, Vincent Al-Mahmeed, Husain Metrakos, Peter BMJ Case Rep Rare Disease A 28-year-old man previously diagnosed and treated for testicular sex cord-stromal tumour (TSCST) presented with symptoms of fever, night sweats and fatigue. Following initial investigations for an infectious aetiology, imaging studies detected two large liver lesions. Histopathological assessment of the tumours revealed that they were metastases from the TSCST for which the patient had radical inguinal orchiectomy and retroperitoneal lymph node dissection 5 years prior. The curative-intent management of the bilobar liver metastases necessitated staged resection due to the chemoresistant and radioresistant properties of TSCST. The size of the lesions was such that procedures to induce rapid liver hypertrophy were required between surgeries. Both liver metastases were successfully removed following this approach. The patient remains recurrence-free 1 year after surgery and has maintained predisease levels of performance. Nevertheless, he continues to be followed for routine CT scans at regular intervals. BMJ Publishing Group 2019-05-22 /pmc/articles/PMC6536236/ /pubmed/31122957 http://dx.doi.org/10.1136/bcr-2018-228857 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Rare Disease Palmieri, Vincent Al-Mahmeed, Husain Metrakos, Peter Bilateral liver metastases from testicular sex cord-stromal tumour |
title | Bilateral liver metastases from testicular sex cord-stromal tumour |
title_full | Bilateral liver metastases from testicular sex cord-stromal tumour |
title_fullStr | Bilateral liver metastases from testicular sex cord-stromal tumour |
title_full_unstemmed | Bilateral liver metastases from testicular sex cord-stromal tumour |
title_short | Bilateral liver metastases from testicular sex cord-stromal tumour |
title_sort | bilateral liver metastases from testicular sex cord-stromal tumour |
topic | Rare Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536236/ https://www.ncbi.nlm.nih.gov/pubmed/31122957 http://dx.doi.org/10.1136/bcr-2018-228857 |
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