Insulin promotes invasion and migration of KRAS(G12D) mutant HPNE cells by upregulating MMP‐2 gelatinolytic activity via ERK‐ and PI3K‐dependent signalling

OBJECTIVES: Hyperinsulinemia is a risk factor for pancreatic cancer, but the function of insulin in carcinogenesis is unclear, so this study aimed to elucidate the carcinogenic effects of insulin and the synergistic effect with the KRAS mutation in the early stage of pancreatic cancer. MATERIALS AND...

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Detalles Bibliográficos
Autores principales: Wang, Guangfu, Yin, Lingdi, Peng, Yunpeng, Gao, Yong, Gao, Hao, Zhang, Jingjing, Lv, Nan, Miao, Yi, Lu, Zipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536446/
https://www.ncbi.nlm.nih.gov/pubmed/30838710
http://dx.doi.org/10.1111/cpr.12575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536446/
https://www.ncbi.nlm.nih.gov/pubmed/30838710
http://dx.doi.org/10.1111/cpr.12575

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