Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial‐lysosomal crosstalk

OBJECTIVES: The genotoxicity of cisplatin towards nuclear DNA is not sufficient to explain the cisplatin resistance of hepatocellular carcinoma (HCC) cells; cisplatin interacts with many organelles, which can influence the sensitivity. Here, we explored the role of mitochondrial‐lysosomal crosstalk...

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Detalles Bibliográficos
Autores principales: Sheng, Jiyao, Shen, Luyan, Sun, Liankun, Zhang, Xuewen, Cui, Ranji, Wang, Lizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536453/
https://www.ncbi.nlm.nih.gov/pubmed/31033054
http://dx.doi.org/10.1111/cpr.12609

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