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Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines

Parthenolide (PT) is a sesquiterpene lactone isolated from Tanacetum parthenium. In this study, PT showed varying cytotoxic effects against different solid tumor cell lines. HCT116 (p53(+/+)) colon carcinoma cells and their parental HCT116 knockout p53 (p53(-/-)) cell lines showed a resistance degre...

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Detalles Bibliográficos
Autores principales:	Dawood, Mona, Ooko, Edna, Efferth, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536578/ https://www.ncbi.nlm.nih.gov/pubmed/31164821 http://dx.doi.org/10.3389/fphar.2019.00542

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