Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures

Pyrrolone-fused benzosuberene (PBS) compounds were semi-synthesized from α,β,γ-Himachalenes extracted from the essential oil of Cedrus deodara following amino-vinyl-bromide substituted benzosuberenes as intermediates. These PBSs compounds classified as an attractive source of therapeutics. The α-iso...

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Detalles Bibliográficos
Autores principales: Tanwar, Garima, Mazumder, Arindam Ghosh, Bhardwaj, Vijay, Kumari, Savita, Bharti, Richa, Yamini, Singh, Damanpreet, Das, Pralay, Purohit, Rituraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536720/
https://www.ncbi.nlm.nih.gov/pubmed/31133639
http://dx.doi.org/10.1038/s41598-019-44264-6

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