Cargando…
Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma
OBJECTIVE: To evaluate whether the combination of magnetic resonance spectroscopy (MRS) and (11)C-methionine positron emission tomography ((11)C-MET PET) could increase accurate diagnostic sensitivity for non-enhancing supratentorial gliomas. MATERIALS AND METHODS: Between February 2012 and December...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Radiology
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536785/ https://www.ncbi.nlm.nih.gov/pubmed/31132822 http://dx.doi.org/10.3348/kjr.2018.0690 |
_version_ | 1783421844948254720 |
---|---|
author | Kudulaiti, Nijiati Qiu, Tianming Lu, Junfeng Zhang, Huiwei Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao Wu, Jinsong |
author_facet | Kudulaiti, Nijiati Qiu, Tianming Lu, Junfeng Zhang, Huiwei Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao Wu, Jinsong |
author_sort | Kudulaiti, Nijiati |
collection | PubMed |
description | OBJECTIVE: To evaluate whether the combination of magnetic resonance spectroscopy (MRS) and (11)C-methionine positron emission tomography ((11)C-MET PET) could increase accurate diagnostic sensitivity for non-enhancing supratentorial gliomas. MATERIALS AND METHODS: Between February 2012 and December 2017, 109 patients with non-enhanced supratentorial lesions on contrast-enhanced MRI were enrolled. Each patient underwent MRS and (11)C-MET PET before treatment. A lesion was considered to be a glioma when either the MRS or (11)C-MET PET results reached the diagnostic threshold. The radiological diagnosis was compared with the pathological diagnosis or medical diagnostic criteria. RESULTS: The sensitivity and specificity were 60.0% and 50.0% for MRS and 75.8% and 50.0% for (11)C-MET PET, respectively. Upon combining the two modalities, the sensitivity and specificity of the imaging-based diagnosis prior to surgery reached 89.5% and 42.9%, respectively. Statistically significant differences in the sensitivities were observed between the combined and individual approaches (MRS alone, 89.5% vs. 60.0%, p < 0.001; (11)C-MET PET alone, 89.5% vs. 75.8%, p = 0.001). However, no significant differences in specificity were observed between the combined and individual modalities. CONCLUSION: The combination of MRS and (11)C-MET PET findings significantly increases accurate diagnostic sensitivity for non-enhancing supratentorial gliomas without significantly lowering the specificity. This finding suggests the potential of the combined MRS and (11)C-MET PET approach in clinical applications. |
format | Online Article Text |
id | pubmed-6536785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Korean Society of Radiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-65367852019-06-04 Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma Kudulaiti, Nijiati Qiu, Tianming Lu, Junfeng Zhang, Huiwei Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao Wu, Jinsong Korean J Radiol Neuroimaging and Head & Neck OBJECTIVE: To evaluate whether the combination of magnetic resonance spectroscopy (MRS) and (11)C-methionine positron emission tomography ((11)C-MET PET) could increase accurate diagnostic sensitivity for non-enhancing supratentorial gliomas. MATERIALS AND METHODS: Between February 2012 and December 2017, 109 patients with non-enhanced supratentorial lesions on contrast-enhanced MRI were enrolled. Each patient underwent MRS and (11)C-MET PET before treatment. A lesion was considered to be a glioma when either the MRS or (11)C-MET PET results reached the diagnostic threshold. The radiological diagnosis was compared with the pathological diagnosis or medical diagnostic criteria. RESULTS: The sensitivity and specificity were 60.0% and 50.0% for MRS and 75.8% and 50.0% for (11)C-MET PET, respectively. Upon combining the two modalities, the sensitivity and specificity of the imaging-based diagnosis prior to surgery reached 89.5% and 42.9%, respectively. Statistically significant differences in the sensitivities were observed between the combined and individual approaches (MRS alone, 89.5% vs. 60.0%, p < 0.001; (11)C-MET PET alone, 89.5% vs. 75.8%, p = 0.001). However, no significant differences in specificity were observed between the combined and individual modalities. CONCLUSION: The combination of MRS and (11)C-MET PET findings significantly increases accurate diagnostic sensitivity for non-enhancing supratentorial gliomas without significantly lowering the specificity. This finding suggests the potential of the combined MRS and (11)C-MET PET approach in clinical applications. The Korean Society of Radiology 2019-06 2019-04-26 /pmc/articles/PMC6536785/ /pubmed/31132822 http://dx.doi.org/10.3348/kjr.2018.0690 Text en Copyright © 2019 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroimaging and Head & Neck Kudulaiti, Nijiati Qiu, Tianming Lu, Junfeng Zhang, Huiwei Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao Wu, Jinsong Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title | Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title_full | Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title_fullStr | Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title_full_unstemmed | Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title_short | Combination of Magnetic Resonance Spectroscopy and (11)C-Methionine Positron Emission Tomography for the Accurate Diagnosis of Non-Enhancing Supratentorial Glioma |
title_sort | combination of magnetic resonance spectroscopy and (11)c-methionine positron emission tomography for the accurate diagnosis of non-enhancing supratentorial glioma |
topic | Neuroimaging and Head & Neck |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536785/ https://www.ncbi.nlm.nih.gov/pubmed/31132822 http://dx.doi.org/10.3348/kjr.2018.0690 |
work_keys_str_mv | AT kudulaitinijiati combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT qiutianming combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT lujunfeng combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT zhanghuiwei combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT zhangzhengwei combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT guanyihui combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT zhuangdongxiao combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma AT wujinsong combinationofmagneticresonancespectroscopyand11cmethioninepositronemissiontomographyfortheaccuratediagnosisofnonenhancingsupratentorialglioma |