Cargando…

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

Tauopathies are neurodegenerative diseases characterized by the intraneuronal accumulation of aggregated tau. The staging of this neurodegenerative process is well established for Alzheimer’s disease as well as for other tauopathies. The stereotypical pattern of tau pathology in these diseases is co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Albert, Marie, Mairet-Coello, Georges, Danis, Clément, Lieger, Sarah, Caillierez, Raphaëlle, Carrier, Sébastien, Skrobala, Emilie, Landrieu, Isabelle, Michel, Anne, Schmitt, Mathieu, Citron, Martin, Downey, Patrick, Courade, Jean-Philippe, Buée, Luc, Colin, Morvane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536853/ https://www.ncbi.nlm.nih.gov/pubmed/31038156 http://dx.doi.org/10.1093/brain/awz100

Ejemplares similares

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
por: Danis, Clément, et al.
Publicado: (2022)

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies
por: Leroux, Elodie, et al.
Publicado: (2022)

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
por: Colin, Morvane, et al.
Publicado: (2019)

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
por: Courade, Jean-Philippe, et al.
Publicado: (2018)

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
por: Dujardin, Simon, et al.
Publicado: (2014)

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
por: Dujardin, Simon, et al.
Publicado: (2014)

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents
por: Rico, Thomas, et al.
Publicado: (2022)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

Neuronal activity enhances tau propagation and tau pathology in vivo
por: Wu, Jessica W., et al.
Publicado: (2016)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
por: Cantrelle, François-Xavier, et al.
Publicado: (2021)

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
por: Tardivel, Meryem, et al.
Publicado: (2016)

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
por: Violet, Marie, et al.
Publicado: (2014)

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat
por: d’Orange, Marie, et al.
Publicado: (2018)

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology
por: Yamada, Kaoru
Publicado: (2017)

EuroTau: towing scientists to tau without tautology
por: Mudher, Amrit, et al.
Publicado: (2017)

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation
por: Lasorsa, Alessia, et al.
Publicado: (2018)

Identification of disulfide cross-linked tau dimer responsible for tau propagation
por: Kim, Dohee, et al.
Publicado: (2015)

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
por: Caballero, Benjamin, et al.
Publicado: (2021)

Formation and Propagation of Tau Oligomeric Seeds
por: Gerson, Julia E., et al.
Publicado: (2013)

Propagation of Tau via Extracellular Vesicles
por: Pérez, Mar, et al.
Publicado: (2019)

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
por: Lasagna-Reeves, Cristian A., et al.
Publicado: (2012)

Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System
por: Perbet, Romain, et al.
Publicado: (2023)

NMR Meets Tau: Insights into Its Function and Pathology
por: Lippens, Guy, et al.
Publicado: (2016)

MicroRNAs and the Regulation of Tau Metabolism
por: Hébert, Sébastien S., et al.
Publicado: (2012)

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation
por: Nicholls, Samantha B., et al.
Publicado: (2017)

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
por: Shafiei, Scott S., et al.
Publicado: (2017)

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
por: Fleeman, Rebecca M., et al.
Publicado: (2021)

Bassoon contributes to tau-seed propagation and neurotoxicity
por: Martinez, Pablo, et al.
Publicado: (2022)

Implication of tau propagation on neurodegeneration in Alzheimer’s disease
por: Lamontagne-Kam, Daniel, et al.
Publicado: (2023)

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8
por: Malia, Thomas J., et al.
Publicado: (2016)

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
por: Domise, Manon, et al.
Publicado: (2016)

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin
por: Mansuroglu, Zeyni, et al.
Publicado: (2016)

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
por: Laurent, Cyril, et al.
Publicado: (2018)

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis
por: Selenica, Maj-Linda B, et al.
Publicado: (2014)

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
por: Španić, Ena, et al.
Publicado: (2019)

Tau propagation is dependent on the genetic background of mouse strains
por: Dujardin, Simon, et al.
Publicado: (2022)

Does proteopathic tau propagate trans-synaptically in the brain?
por: Hu, Wen, et al.
Publicado: (2022)

Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice
por: Masuda-Suzukake, Masami, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ueu7uftoolp6r0f8cldph0bc53