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Functional connectivity of language networks after perinatal stroke

Successful language acquisition during development is imperative for lifelong function. Complex language networks develop throughout childhood. Perinatal stroke may cause significant language disabilities but function can also be remarkably normal. Studying such very early brain injury populations m...

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Detalles Bibliográficos
Autores principales: Carlson, Helen L., Sugden, Cole, Brooks, Brian L., Kirton, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536856/
https://www.ncbi.nlm.nih.gov/pubmed/31141787
http://dx.doi.org/10.1016/j.nicl.2019.101861
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author Carlson, Helen L.
Sugden, Cole
Brooks, Brian L.
Kirton, Adam
author_facet Carlson, Helen L.
Sugden, Cole
Brooks, Brian L.
Kirton, Adam
author_sort Carlson, Helen L.
collection PubMed
description Successful language acquisition during development is imperative for lifelong function. Complex language networks develop throughout childhood. Perinatal stroke may cause significant language disabilities but function can also be remarkably normal. Studying such very early brain injury populations may inform developmental plasticity models of language networks. We examined functional connectivity (FC) of language networks in children with arterial and venous perinatal stroke and typically developing controls (TDC) in a population-based, controlled, cohort study. Resting state functional MRI was performed at 3 T (TR/TE = 2000/30 ms, 150 volumes, 3.6mm(3) voxels). Seed-based analyses used bilateral inferior frontal and superior temporal gyri. A subset of stroke participants completed clinical language testing. Sixty-six children participated (median age: 12.85±3.8y, range 6–19; arterial N = 17; venous N = 15; TDC N = 34]. Children with left hemisphere strokes had comparable FC in their right hemispheres compared to TDC. Inter- and intra-hemispheric connectivity strengths were similar between TDC and PVI but lower for AIS. Reduced FC was associated with poorer language comprehension. Language networks can be estimated using resting-state fMRI in children with perinatal stroke. Altered connectivity may occur in both hemispheres, is more pronounced with arterial lesions, and is associated with clinical function. Our results have implications for therapeutic language interventions after early stroke.
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spelling pubmed-65368562019-06-03 Functional connectivity of language networks after perinatal stroke Carlson, Helen L. Sugden, Cole Brooks, Brian L. Kirton, Adam Neuroimage Clin Regular Article Successful language acquisition during development is imperative for lifelong function. Complex language networks develop throughout childhood. Perinatal stroke may cause significant language disabilities but function can also be remarkably normal. Studying such very early brain injury populations may inform developmental plasticity models of language networks. We examined functional connectivity (FC) of language networks in children with arterial and venous perinatal stroke and typically developing controls (TDC) in a population-based, controlled, cohort study. Resting state functional MRI was performed at 3 T (TR/TE = 2000/30 ms, 150 volumes, 3.6mm(3) voxels). Seed-based analyses used bilateral inferior frontal and superior temporal gyri. A subset of stroke participants completed clinical language testing. Sixty-six children participated (median age: 12.85±3.8y, range 6–19; arterial N = 17; venous N = 15; TDC N = 34]. Children with left hemisphere strokes had comparable FC in their right hemispheres compared to TDC. Inter- and intra-hemispheric connectivity strengths were similar between TDC and PVI but lower for AIS. Reduced FC was associated with poorer language comprehension. Language networks can be estimated using resting-state fMRI in children with perinatal stroke. Altered connectivity may occur in both hemispheres, is more pronounced with arterial lesions, and is associated with clinical function. Our results have implications for therapeutic language interventions after early stroke. Elsevier 2019-05-21 /pmc/articles/PMC6536856/ /pubmed/31141787 http://dx.doi.org/10.1016/j.nicl.2019.101861 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Carlson, Helen L.
Sugden, Cole
Brooks, Brian L.
Kirton, Adam
Functional connectivity of language networks after perinatal stroke
title Functional connectivity of language networks after perinatal stroke
title_full Functional connectivity of language networks after perinatal stroke
title_fullStr Functional connectivity of language networks after perinatal stroke
title_full_unstemmed Functional connectivity of language networks after perinatal stroke
title_short Functional connectivity of language networks after perinatal stroke
title_sort functional connectivity of language networks after perinatal stroke
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536856/
https://www.ncbi.nlm.nih.gov/pubmed/31141787
http://dx.doi.org/10.1016/j.nicl.2019.101861
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