Loss of STEP(61) couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing

Dysregulated excitability within the spinal dorsal horn is a critical mediator of chronic pain. In the rodent nerve injury model of neuropathic pain, BDNF-mediated loss of inhibition (disinhibition) gates the potentiation of excitatory GluN2B N-methyl-d-aspartate receptor (NMDAR) responses at lamina...

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Detalles Bibliográficos
Autores principales: Dedek, Annemarie, Xu, Jian, Kandegedara, Chaya M, Lorenzo, Louis-Étienne, Godin, Antoine G, De Koninck, Yves, Lombroso, Paul J, Tsai, Eve C, Hildebrand, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536915/
https://www.ncbi.nlm.nih.gov/pubmed/31135041
http://dx.doi.org/10.1093/brain/awz105

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