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The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry
In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS‐R)....
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536924/ https://www.ncbi.nlm.nih.gov/pubmed/30897290 http://dx.doi.org/10.1002/cam4.2090 |
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author | Diamantopoulos, Panagiotis Koumbi, Dafni Kotsianidis, Ioannis Pappa, Vasiliki Symeonidis, Argiris Galanopoulos, Athanasios Zikos, Panagiotis Papadaki, Helen A. Panayiotidis, Panayiotis Dimou, Maria Hatzimichael, Eleftheria Vassilopoulos, George Delimpasis, Susan Mparmparousi, Despoina Papageorgiou, Sotirios Variami, Eleni Kyrtsonis, Marie‐Christine Megalakaki, Aekaterini Kotsopoulou, Maria Repousis, Panagiotis Adamopoulos, Ioannis Kontopidou, Flora Christoulas, Dimitrios Kourakli, Alexandra Tsokanas, Dimitrios Konstantinos Papoutselis, Menelaos Kyriakakis, Georgios Viniou, Nora‐Athina |
author_facet | Diamantopoulos, Panagiotis Koumbi, Dafni Kotsianidis, Ioannis Pappa, Vasiliki Symeonidis, Argiris Galanopoulos, Athanasios Zikos, Panagiotis Papadaki, Helen A. Panayiotidis, Panayiotis Dimou, Maria Hatzimichael, Eleftheria Vassilopoulos, George Delimpasis, Susan Mparmparousi, Despoina Papageorgiou, Sotirios Variami, Eleni Kyrtsonis, Marie‐Christine Megalakaki, Aekaterini Kotsopoulou, Maria Repousis, Panagiotis Adamopoulos, Ioannis Kontopidou, Flora Christoulas, Dimitrios Kourakli, Alexandra Tsokanas, Dimitrios Konstantinos Papoutselis, Menelaos Kyriakakis, Georgios Viniou, Nora‐Athina |
author_sort | Diamantopoulos, Panagiotis |
collection | PubMed |
description | In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS‐R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5‐azacytidine through the Hellenic 5‐azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with ‐17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS‐R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan–Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality. |
format | Online Article Text |
id | pubmed-6536924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65369242019-06-03 The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry Diamantopoulos, Panagiotis Koumbi, Dafni Kotsianidis, Ioannis Pappa, Vasiliki Symeonidis, Argiris Galanopoulos, Athanasios Zikos, Panagiotis Papadaki, Helen A. Panayiotidis, Panayiotis Dimou, Maria Hatzimichael, Eleftheria Vassilopoulos, George Delimpasis, Susan Mparmparousi, Despoina Papageorgiou, Sotirios Variami, Eleni Kyrtsonis, Marie‐Christine Megalakaki, Aekaterini Kotsopoulou, Maria Repousis, Panagiotis Adamopoulos, Ioannis Kontopidou, Flora Christoulas, Dimitrios Kourakli, Alexandra Tsokanas, Dimitrios Konstantinos Papoutselis, Menelaos Kyriakakis, Georgios Viniou, Nora‐Athina Cancer Med Clinical Cancer Research In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS‐R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5‐azacytidine through the Hellenic 5‐azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with ‐17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS‐R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan–Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality. John Wiley and Sons Inc. 2019-03-21 /pmc/articles/PMC6536924/ /pubmed/30897290 http://dx.doi.org/10.1002/cam4.2090 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Diamantopoulos, Panagiotis Koumbi, Dafni Kotsianidis, Ioannis Pappa, Vasiliki Symeonidis, Argiris Galanopoulos, Athanasios Zikos, Panagiotis Papadaki, Helen A. Panayiotidis, Panayiotis Dimou, Maria Hatzimichael, Eleftheria Vassilopoulos, George Delimpasis, Susan Mparmparousi, Despoina Papageorgiou, Sotirios Variami, Eleni Kyrtsonis, Marie‐Christine Megalakaki, Aekaterini Kotsopoulou, Maria Repousis, Panagiotis Adamopoulos, Ioannis Kontopidou, Flora Christoulas, Dimitrios Kourakli, Alexandra Tsokanas, Dimitrios Konstantinos Papoutselis, Menelaos Kyriakakis, Georgios Viniou, Nora‐Athina The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title | The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title_full | The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title_fullStr | The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title_full_unstemmed | The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title_short | The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry |
title_sort | prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: results from the hellenic 5‐azacytidine registry |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536924/ https://www.ncbi.nlm.nih.gov/pubmed/30897290 http://dx.doi.org/10.1002/cam4.2090 |
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