Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

The protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental models; however, its efficacy in patients has not been elucidated. The aim of this study was to investigate the possible protective effect of NAC on cisplatin‐induced toxic...

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Detalles Bibliográficos
Autores principales: Visacri, Marília B., Quintanilha, Júlia C. F., de Sousa, Vanessa M., Amaral, Laís S., de F. L. Ambrósio, Rosiane, Calonga, Luciane, Curi, Silvia F. B. B., de T. Leme, Mayra F., Chone, Carlos T., Altemani, João M. C., Mazzola, Priscila G., Malaguti, Carina, Vercesi, Aníbal E., Lima, Carmen S. P., Moriel, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536930/
https://www.ncbi.nlm.nih.gov/pubmed/30977273
http://dx.doi.org/10.1002/cam4.2072

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