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Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial
BACKGROUND: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3–6 months after acute optic neuritis. OB...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537072/ https://www.ncbi.nlm.nih.gov/pubmed/31205740 http://dx.doi.org/10.1177/2055217319850193 |
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author | Falardeau, Julie Fryman, Allison Wanchu, Rohan Marracci, Gail H Mass, Michele Wooliscroft, Lindsey Bourdette, Dennis N Murchison, Charles F Hills, William L Yadav, Vijayshree |
author_facet | Falardeau, Julie Fryman, Allison Wanchu, Rohan Marracci, Gail H Mass, Michele Wooliscroft, Lindsey Bourdette, Dennis N Murchison, Charles F Hills, William L Yadav, Vijayshree |
author_sort | Falardeau, Julie |
collection | PubMed |
description | BACKGROUND: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3–6 months after acute optic neuritis. OBJECTIVE: To determine whether lipoic acid is neuroprotective in acute optic neuritis. METHODS: A single-center, double-blind, randomized, placebo controlled, 24-week trial. Intervention included 6 weeks of once daily lipoic acid (1200 mg) or placebo within 14 days of acute optic neuritis diagnosis. The primary outcome was the mean difference in affected eye retinal nerve fiber layer (RNFL) thickness from baseline to 24 weeks. RESULTS: We enrolled 31 subjects (placebo n=16; lipoic acid n=15; average age 38.6 years (standard deviation (SD) 10.3)). Affected eye mean global RNFL thickness (µm) in the lipoic acid group decreased from 108.47 (SD 26.11) at baseline to 79.31 (SD 19.26) at 24 weeks. The affected eye RNFL in the placebo group decreased from 103.67 (SD 18.04) at baseline to 84.43 (SD 20.94) at 24 weeks. Unaffected eye RNFL thickness did not significantly change in either group over 24 weeks. CONCLUSION: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis. |
format | Online Article Text |
id | pubmed-6537072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65370722019-06-14 Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial Falardeau, Julie Fryman, Allison Wanchu, Rohan Marracci, Gail H Mass, Michele Wooliscroft, Lindsey Bourdette, Dennis N Murchison, Charles F Hills, William L Yadav, Vijayshree Mult Scler J Exp Transl Clin Original Research Paper BACKGROUND: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3–6 months after acute optic neuritis. OBJECTIVE: To determine whether lipoic acid is neuroprotective in acute optic neuritis. METHODS: A single-center, double-blind, randomized, placebo controlled, 24-week trial. Intervention included 6 weeks of once daily lipoic acid (1200 mg) or placebo within 14 days of acute optic neuritis diagnosis. The primary outcome was the mean difference in affected eye retinal nerve fiber layer (RNFL) thickness from baseline to 24 weeks. RESULTS: We enrolled 31 subjects (placebo n=16; lipoic acid n=15; average age 38.6 years (standard deviation (SD) 10.3)). Affected eye mean global RNFL thickness (µm) in the lipoic acid group decreased from 108.47 (SD 26.11) at baseline to 79.31 (SD 19.26) at 24 weeks. The affected eye RNFL in the placebo group decreased from 103.67 (SD 18.04) at baseline to 84.43 (SD 20.94) at 24 weeks. Unaffected eye RNFL thickness did not significantly change in either group over 24 weeks. CONCLUSION: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis. SAGE Publications 2019-05-13 /pmc/articles/PMC6537072/ /pubmed/31205740 http://dx.doi.org/10.1177/2055217319850193 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Paper Falardeau, Julie Fryman, Allison Wanchu, Rohan Marracci, Gail H Mass, Michele Wooliscroft, Lindsey Bourdette, Dennis N Murchison, Charles F Hills, William L Yadav, Vijayshree Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title | Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title_full | Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title_fullStr | Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title_full_unstemmed | Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title_short | Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
title_sort | oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537072/ https://www.ncbi.nlm.nih.gov/pubmed/31205740 http://dx.doi.org/10.1177/2055217319850193 |
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