Cargando…

Human translingual neurostimulation alters resting brain activity in high-density EEG

BACKGROUND: Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive. OBJECTIVE: To investigate physiological evidence of central nervous system (CNS) changes in humans during translingu...

Descripción completa

Detalles Bibliográficos
Autores principales: Frehlick, Zack, Lakhani, Bimal, Fickling, Shaun D., Livingstone, Ashley C., Danilov, Yuri, Sackier, Jonathan M., D’Arcy, Ryan C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537158/
https://www.ncbi.nlm.nih.gov/pubmed/31133021
http://dx.doi.org/10.1186/s12984-019-0538-4
_version_ 1783421938717163520
author Frehlick, Zack
Lakhani, Bimal
Fickling, Shaun D.
Livingstone, Ashley C.
Danilov, Yuri
Sackier, Jonathan M.
D’Arcy, Ryan C. N.
author_facet Frehlick, Zack
Lakhani, Bimal
Fickling, Shaun D.
Livingstone, Ashley C.
Danilov, Yuri
Sackier, Jonathan M.
D’Arcy, Ryan C. N.
author_sort Frehlick, Zack
collection PubMed
description BACKGROUND: Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive. OBJECTIVE: To investigate physiological evidence of central nervous system (CNS) changes in humans during translingual neurostimulation (TLNS). METHODS: We used high-density electroencephalography (EEG) to measure changes in resting brain activity before, during, and after high frequency (HF) and low frequency (LF) TLNS. RESULTS: Wavelet power analysis around Cz and microstate analysis revealed significant changes after 20 min of stimulation compared to baseline. A secondary effect of exposure order was also identified, indicating a differential neuromodulatory influence of HF TLNS relative to LF TLNS on alpha and theta signal power. CONCLUSIONS: These results further our understanding of the effects of TLNS on underlying resting brain activity, which in the long-term may contribute to the critical link between clinical effect and changes in brain activity.
format Online
Article
Text
id pubmed-6537158
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-65371582019-05-30 Human translingual neurostimulation alters resting brain activity in high-density EEG Frehlick, Zack Lakhani, Bimal Fickling, Shaun D. Livingstone, Ashley C. Danilov, Yuri Sackier, Jonathan M. D’Arcy, Ryan C. N. J Neuroeng Rehabil Research BACKGROUND: Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive. OBJECTIVE: To investigate physiological evidence of central nervous system (CNS) changes in humans during translingual neurostimulation (TLNS). METHODS: We used high-density electroencephalography (EEG) to measure changes in resting brain activity before, during, and after high frequency (HF) and low frequency (LF) TLNS. RESULTS: Wavelet power analysis around Cz and microstate analysis revealed significant changes after 20 min of stimulation compared to baseline. A secondary effect of exposure order was also identified, indicating a differential neuromodulatory influence of HF TLNS relative to LF TLNS on alpha and theta signal power. CONCLUSIONS: These results further our understanding of the effects of TLNS on underlying resting brain activity, which in the long-term may contribute to the critical link between clinical effect and changes in brain activity. BioMed Central 2019-05-27 /pmc/articles/PMC6537158/ /pubmed/31133021 http://dx.doi.org/10.1186/s12984-019-0538-4 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Frehlick, Zack
Lakhani, Bimal
Fickling, Shaun D.
Livingstone, Ashley C.
Danilov, Yuri
Sackier, Jonathan M.
D’Arcy, Ryan C. N.
Human translingual neurostimulation alters resting brain activity in high-density EEG
title Human translingual neurostimulation alters resting brain activity in high-density EEG
title_full Human translingual neurostimulation alters resting brain activity in high-density EEG
title_fullStr Human translingual neurostimulation alters resting brain activity in high-density EEG
title_full_unstemmed Human translingual neurostimulation alters resting brain activity in high-density EEG
title_short Human translingual neurostimulation alters resting brain activity in high-density EEG
title_sort human translingual neurostimulation alters resting brain activity in high-density eeg
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537158/
https://www.ncbi.nlm.nih.gov/pubmed/31133021
http://dx.doi.org/10.1186/s12984-019-0538-4
work_keys_str_mv AT frehlickzack humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT lakhanibimal humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT ficklingshaund humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT livingstoneashleyc humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT danilovyuri humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT sackierjonathanm humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg
AT darcyryancn humantranslingualneurostimulationaltersrestingbrainactivityinhighdensityeeg