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Somatic mutation and clonal expansions in human tissues
Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding o...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537184/ https://www.ncbi.nlm.nih.gov/pubmed/31138277 http://dx.doi.org/10.1186/s13073-019-0648-4 |
| _version_ | 1783421946318290944 |
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| author | Martincorena, Inigo |
| author_facet | Martincorena, Inigo |
| author_sort | Martincorena, Inigo |
| collection | PubMed |
| description | Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases. |
| format | Online Article Text |
| id | pubmed-6537184 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65371842019-05-30 Somatic mutation and clonal expansions in human tissues Martincorena, Inigo Genome Med Comment Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding of cancer, ageing, and other diseases. BioMed Central 2019-05-28 /pmc/articles/PMC6537184/ /pubmed/31138277 http://dx.doi.org/10.1186/s13073-019-0648-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Comment Martincorena, Inigo Somatic mutation and clonal expansions in human tissues |
| title | Somatic mutation and clonal expansions in human tissues |
| title_full | Somatic mutation and clonal expansions in human tissues |
| title_fullStr | Somatic mutation and clonal expansions in human tissues |
| title_full_unstemmed | Somatic mutation and clonal expansions in human tissues |
| title_short | Somatic mutation and clonal expansions in human tissues |
| title_sort | somatic mutation and clonal expansions in human tissues |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537184/ https://www.ncbi.nlm.nih.gov/pubmed/31138277 http://dx.doi.org/10.1186/s13073-019-0648-4 |
| work_keys_str_mv | AT martincorenainigo somaticmutationandclonalexpansionsinhumantissues |