Circular RNAs and RNase L in PKR activation and virus infection

Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports...

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Autor principal: Zheng, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537376/
https://www.ncbi.nlm.nih.gov/pubmed/31149330
http://dx.doi.org/10.1186/s13578-019-0307-x
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author Zheng, Zhi-Ming
author_facet Zheng, Zhi-Ming
author_sort Zheng, Zhi-Ming
collection PubMed
description Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports an important role of circRNAs in antiviral innate immunity by binding PKR as PKR inhibitors. Rapid degradation of circRNAs by activated RNase L from virus infection or poly I:C stimulation is required to free PKR for its activation. Systemic lupus erythematosus patients remark with circRNA reduction and aberrant PKR activation.
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spelling pubmed-65373762019-05-30 Circular RNAs and RNase L in PKR activation and virus infection Zheng, Zhi-Ming Cell Biosci Research Highlight Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports an important role of circRNAs in antiviral innate immunity by binding PKR as PKR inhibitors. Rapid degradation of circRNAs by activated RNase L from virus infection or poly I:C stimulation is required to free PKR for its activation. Systemic lupus erythematosus patients remark with circRNA reduction and aberrant PKR activation. BioMed Central 2019-05-27 /pmc/articles/PMC6537376/ /pubmed/31149330 http://dx.doi.org/10.1186/s13578-019-0307-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Zheng, Zhi-Ming
Circular RNAs and RNase L in PKR activation and virus infection
title Circular RNAs and RNase L in PKR activation and virus infection
title_full Circular RNAs and RNase L in PKR activation and virus infection
title_fullStr Circular RNAs and RNase L in PKR activation and virus infection
title_full_unstemmed Circular RNAs and RNase L in PKR activation and virus infection
title_short Circular RNAs and RNase L in PKR activation and virus infection
title_sort circular rnas and rnase l in pkr activation and virus infection
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537376/
https://www.ncbi.nlm.nih.gov/pubmed/31149330
http://dx.doi.org/10.1186/s13578-019-0307-x
work_keys_str_mv AT zhengzhiming circularrnasandrnaselinpkractivationandvirusinfection

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