A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice

BACKGROUND: Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β superfamily. The GDF11 propeptide, which is derived from the GDF11 precursor protein, blocks the activity of GDF11 and its homolog, myostatin, which are both potent inhibitors of muscle growth. Thus,...

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Detalles Bibliográficos
Autores principales: Jin, Quan, Qiao, Chunping, Li, Jianbin, Xiao, Bin, Li, Juan, Xiao, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537384/
https://www.ncbi.nlm.nih.gov/pubmed/31133057
http://dx.doi.org/10.1186/s13395-019-0197-y

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