Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells

BACKGROUND: The bcr-abl fusion gene encodes BCR-ABL oncoprotein and plays a crucial role in the leukemogenesis of chronic myeloid leukemia (CML). Current therapeutic methods have limited treatment effect on CML patients with drug resistance or disease relapse. Therefore, novel therapeutic strategy f...

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Detalles Bibliográficos
Autores principales: Luo, Zhenhong, Gao, Miao, Huang, Ningshu, Wang, Xin, Yang, Zesong, Yang, Hao, Huang, Zhenglan, Feng, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537404/
https://www.ncbi.nlm.nih.gov/pubmed/31138265
http://dx.doi.org/10.1186/s13046-019-1229-5

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