Cargando…

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4(+) T lymphocyte activation

BACKGROUND: The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP-1 and NFAT and subsequent interleukin-2 expression, but also critical for posi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siegmund, Kerstin, Thuille, Nikolaus, Posch, Nina, Fresser, Friedrich, Leitges, Michael, Baier, Gottfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537413/ https://www.ncbi.nlm.nih.gov/pubmed/31138259 http://dx.doi.org/10.1186/s12964-019-0364-0

Ejemplares similares

Novel Protein kinase C θ: Coronin 1A complex in T lymphocytes
por: Siegmund, Kerstin, et al.
Publicado: (2015)

Protein kinase C theta is dispensable for suppression mediated by CD25(+)CD4(+) regulatory T cells
por: Siegmund, Kerstin, et al.
Publicado: (2017)

PKCθ/β and CYLD Are Antagonistic Partners in the NFκB and NFAT Transactivation Pathways in Primary Mouse CD3(+) T Lymphocytes
por: Thuille, Nikolaus, et al.
Publicado: (2013)

Loss-of-function phenotype of a PKCθ(T219A) knockin mouse strain
por: Thuille, Nikolaus, et al.
Publicado: (2019)

A MLR-Based Approach to Analyze Regulators of T Lymphocyte Activation In Vivo
por: Koutník, Jiří, et al.
Publicado: (2022)

Protein Kinase C θ Regulates the Phenotype of Murine CD4(+) Th17 Cells
por: Wachowicz, Katarzyna, et al.
Publicado: (2014)

Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter
por: Hermann-Kleiter, Natascha, et al.
Publicado: (2012)

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
por: Christina, Lutz-Nicoladoni, et al.
Publicado: (2013)

Corrigendum to “PKC∝ and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription” [Immunol. Lett. 151 (1–2) (2013) 31–38)]
por: Lutz-Nicoladoni, Christina, et al.
Publicado: (2014)

Involvement of distinct PKC gene products in T cell functions
por: Pfeifhofer-Obermair, Christa, et al.
Publicado: (2012)

The Kinase PKCα Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses
por: Meisel, Marlies, et al.
Publicado: (2013)

T cell-intrinsic protein kinase D3 is dispensable for the cells’ activation
por: Koutník, Jiří, et al.
Publicado: (2022)

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice
por: Pfeifhofer-Obermair, Christa, et al.
Publicado: (2016)

Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc
por: Haller, Martina, et al.
Publicado: (2016)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

Protein kinase N1 critically regulates cerebellar development and long-term function
por: zur Nedden, Stephanie, et al.
Publicado: (2018)

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6
por: Klepsch, Victoria, et al.
Publicado: (2021)

PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic–Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling
por: zur Nedden, Stephanie, et al.
Publicado: (2023)

Addressing the role of PKD3 in the T cell compartment with knockout mice
por: Koutník, Jiří, et al.
Publicado: (2022)

DECAAF: Emphasizing the importance of MRI in AF ablation
por: ElMaghawry, Mohamed, et al.
Publicado: (2015)

Protein Kinase C θ Affects Ca(2+) Mobilization and NFAT Activation in Primary Mouse T Cells
por: Pfeifhofer, Christa, et al.
Publicado: (2003)

LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells
por: Thauerer, Bettina, et al.
Publicado: (2014)

Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
por: Iba, Toshiaki, et al.
Publicado: (2022)

A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma
por: Ram, Nanik, et al.
Publicado: (2020)

The importance of emphasizing role-modelling in the CanMEDS framework to enhance medical education
por: Kim, Isaac, et al.
Publicado: (2023)

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity
por: Strasser, Dominikus, et al.
Publicado: (2012)

Areca Nut Chewing: Initiation, Addiction, and Harmful Effects Emphasizing the Barriers and Importance of Cessation
por: Athukorala, I. A., et al.
Publicado: (2021)

3D printing in surgical simulation: emphasized importance in the COVID-19 pandemic era
por: Michaels, Ross, et al.
Publicado: (2021)

Emergent Computation: Emphasizing Bioinformatics
por: Simon, Matthew
Publicado: (2005)

Releasing the Brake: Targeting Cbl-b to Enhance Lymphocyte Effector Functions
por: Wallner, Stephanie, et al.
Publicado: (2012)

A rare case of recurrent primary anorectal melanoma emphasizing the importance of postoperative follow-ups
por: Li, Zhihao, et al.
Publicado: (2020)

A Case of STEMI Masquerading Brugada Syndrome: Emphasizing the Importance of Clinical Decision Making in Emergencies
por: Guragai, Nirmal, et al.
Publicado: (2021)

An opportunity to emphasize the relevance of laboratory medicine
por: Santamaría González, María, et al.
Publicado: (2021)

Occupational Injuries in Germany: Population-Wide National Survey Data Emphasize the Importance of Work-Related Factors
por: Rommel, Alexander, et al.
Publicado: (2016)

PD-L1 pitfalls: Emphasizing the importance of membranous localization and correlation with tumor cell and macrophage distributions
por: Mills, Anne M., et al.
Publicado: (2017)

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers
por: Dickson, Dennis W., et al.
Publicado: (2019)

Pathological and bacteriological studies on reproductive tract abnormalities of she-camels (Camelus dromedarius), emphasizing on zoonotic importance
por: Elshazly, Mohamed Osama, et al.
Publicado: (2020)

Increased visual and cognitive demands emphasize the importance of meeting visual needs at all distances while driving
por: Patoine, Amigale, et al.
Publicado: (2021)

The revitalization of “Osekkai”: How the COVID-19 pandemic has emphasized the importance of Japanese voluntary social work
por: Ohta, Ryuichi, et al.
Publicado: (2021)

Molecular genetics and structural genomics of the human protein kinase C gene module
por: Kofler, Kurt, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_sj3kcir3svb0l8l0g23bbvj5io