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Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis

Background: Accumulating evidence has demonstrated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) (referred to as miR-SNPs) participate in the process of carcinogenesis by altering the expression and structure of mature miRNAs. However, the associations between several previously...

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Autores principales: Guo, Xudong, Zhao, Lei, Shen, Yi, Shao, Yi, Wei, Wenqiang, Liu, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537464/
https://www.ncbi.nlm.nih.gov/pubmed/31213825
http://dx.doi.org/10.2147/OTT.S193958
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author Guo, Xudong
Zhao, Lei
Shen, Yi
Shao, Yi
Wei, Wenqiang
Liu, Fen
author_facet Guo, Xudong
Zhao, Lei
Shen, Yi
Shao, Yi
Wei, Wenqiang
Liu, Fen
author_sort Guo, Xudong
collection PubMed
description Background: Accumulating evidence has demonstrated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) (referred to as miR-SNPs) participate in the process of carcinogenesis by altering the expression and structure of mature miRNAs. However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. We, therefore, performed a comprehensive meta-analysis to systemically evaluate the correlation of genetic polymorphisms in these four miRNAs with the risk of ESCC. Methods: Relevant studies were searched in PubMed and other electronic databases up to August 2018, supplemented by a manual search of references from retrieved articles. The pooled ORs with 95% CIs were calculated using a random-effects model. Results: A total of 22 studies from 13 published articles were included in the meta-analysis. All studies have a relatively high score of quality assessment. The pooled analysis indicated that individuals with the variant TT genotype of rs11614913 in miR-196a2 gene have a significantly decreased risk of ESCC compared with CC genotype (OR =0.83, 95% CI: 0.73–0.95). The decreased risk of ESCC was also shown in the recessive model (TT vs CT/CC: OR=0.86, 95%CI: 0.77–0.96) and allele model (T vs C: OR=0.93, 95%CI: 0.87–0.99). The significantly reduced risk of ESCC was also observed in the polymorphisms of the miR-34b/c rs4938723 locus. The similar tendency was presented in the subgroup of Chinese Han population when stratified by ethnicity. However, no significant associations were observed in the miR-146a rs2910164 and miR-423 rs6505162 with the susceptibility of ESCC in any genetic model. Conclusion: Our results suggested that the polymorphisms of miR-196a and miR-34b/c genes were related to the risk of ESCC, especially among Chinese. The findings of this study, however, need to be confirmed in further researches.
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spelling pubmed-65374642019-06-18 Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis Guo, Xudong Zhao, Lei Shen, Yi Shao, Yi Wei, Wenqiang Liu, Fen Onco Targets Ther Original Research Background: Accumulating evidence has demonstrated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) (referred to as miR-SNPs) participate in the process of carcinogenesis by altering the expression and structure of mature miRNAs. However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. We, therefore, performed a comprehensive meta-analysis to systemically evaluate the correlation of genetic polymorphisms in these four miRNAs with the risk of ESCC. Methods: Relevant studies were searched in PubMed and other electronic databases up to August 2018, supplemented by a manual search of references from retrieved articles. The pooled ORs with 95% CIs were calculated using a random-effects model. Results: A total of 22 studies from 13 published articles were included in the meta-analysis. All studies have a relatively high score of quality assessment. The pooled analysis indicated that individuals with the variant TT genotype of rs11614913 in miR-196a2 gene have a significantly decreased risk of ESCC compared with CC genotype (OR =0.83, 95% CI: 0.73–0.95). The decreased risk of ESCC was also shown in the recessive model (TT vs CT/CC: OR=0.86, 95%CI: 0.77–0.96) and allele model (T vs C: OR=0.93, 95%CI: 0.87–0.99). The significantly reduced risk of ESCC was also observed in the polymorphisms of the miR-34b/c rs4938723 locus. The similar tendency was presented in the subgroup of Chinese Han population when stratified by ethnicity. However, no significant associations were observed in the miR-146a rs2910164 and miR-423 rs6505162 with the susceptibility of ESCC in any genetic model. Conclusion: Our results suggested that the polymorphisms of miR-196a and miR-34b/c genes were related to the risk of ESCC, especially among Chinese. The findings of this study, however, need to be confirmed in further researches. Dove 2019-05-23 /pmc/articles/PMC6537464/ /pubmed/31213825 http://dx.doi.org/10.2147/OTT.S193958 Text en © 2019 Guo et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Guo, Xudong
Zhao, Lei
Shen, Yi
Shao, Yi
Wei, Wenqiang
Liu, Fen
Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title_full Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title_fullStr Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title_full_unstemmed Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title_short Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
title_sort polymorphism of mirna and esophageal cancer risk: an updated systemic review and meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537464/
https://www.ncbi.nlm.nih.gov/pubmed/31213825
http://dx.doi.org/10.2147/OTT.S193958
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