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Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort

BACKGROUND: The increasing incidence of allergic diseases highlights the importance of finding underlying mechanisms. Early vaccination has been suggested as one influential factor. However, it is difficult to find a study group with a large variation between subjects concerning compliance to the of...

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Autores principales: Swartz, Jackie, Aronsson, Bernice, Lindblad, Frank, Järnbert-Pettersson, Hans, Scheynius, Annika, Pershagen, Göran, Alm, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537579/
https://www.ncbi.nlm.nih.gov/pubmed/31193660
http://dx.doi.org/10.1016/j.eclinm.2018.10.005
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author Swartz, Jackie
Aronsson, Bernice
Lindblad, Frank
Järnbert-Pettersson, Hans
Scheynius, Annika
Pershagen, Göran
Alm, Johan
author_facet Swartz, Jackie
Aronsson, Bernice
Lindblad, Frank
Järnbert-Pettersson, Hans
Scheynius, Annika
Pershagen, Göran
Alm, Johan
author_sort Swartz, Jackie
collection PubMed
description BACKGROUND: The increasing incidence of allergic diseases highlights the importance of finding underlying mechanisms. Early vaccination has been suggested as one influential factor. However, it is difficult to find a study group with a large variation between subjects concerning compliance to the official vaccination program. The anthroposophic lifestyle is of interest in this context. Moreover, cohort studies show that children of families with this lifestyle run a lower risk of allergic sensitization and allergy-related disease. METHODS: From the prospective birth cohort ALADDIN we included one group from the anthroposophic community, with restrictive attitudes concerning vaccinations, and two other groups of age-matched children with more conventional parental lifestyles. In all, 466 children were followed from birth to five years of age. Detailed vaccination data and blood samples were collected at six months, one, two, and five years. Information was also obtained on risk factors for allergy. The outcome variable, allergic sensitization was defined as allergen-specific serum IgE levels ≥ 0.35 kU(A)/L. FINDINGS: In a logistic regression model adjusted for socio-demographics and established allergy risk factors, vaccination at later age or having a lower number of injections or vaccines were associated with low OR for allergic sensitization during the first year of life. However, after adjustment for anthroposophic lifestyle, no statistically significant associations remained. The adjusted OR for sensitization at five years of age in children not receiving any vaccinations (n = 54) was 0.98 [95% CI 0.38–2.57]. INTERPRETATION: We found no support for an association between early childhood vaccination and subsequent allergic sensitization. Our findings do not support scepticism towards early childhood vaccination motivated by allergy risk.
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spelling pubmed-65375792019-05-29 Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort Swartz, Jackie Aronsson, Bernice Lindblad, Frank Järnbert-Pettersson, Hans Scheynius, Annika Pershagen, Göran Alm, Johan EClinicalMedicine Research Paper BACKGROUND: The increasing incidence of allergic diseases highlights the importance of finding underlying mechanisms. Early vaccination has been suggested as one influential factor. However, it is difficult to find a study group with a large variation between subjects concerning compliance to the official vaccination program. The anthroposophic lifestyle is of interest in this context. Moreover, cohort studies show that children of families with this lifestyle run a lower risk of allergic sensitization and allergy-related disease. METHODS: From the prospective birth cohort ALADDIN we included one group from the anthroposophic community, with restrictive attitudes concerning vaccinations, and two other groups of age-matched children with more conventional parental lifestyles. In all, 466 children were followed from birth to five years of age. Detailed vaccination data and blood samples were collected at six months, one, two, and five years. Information was also obtained on risk factors for allergy. The outcome variable, allergic sensitization was defined as allergen-specific serum IgE levels ≥ 0.35 kU(A)/L. FINDINGS: In a logistic regression model adjusted for socio-demographics and established allergy risk factors, vaccination at later age or having a lower number of injections or vaccines were associated with low OR for allergic sensitization during the first year of life. However, after adjustment for anthroposophic lifestyle, no statistically significant associations remained. The adjusted OR for sensitization at five years of age in children not receiving any vaccinations (n = 54) was 0.98 [95% CI 0.38–2.57]. INTERPRETATION: We found no support for an association between early childhood vaccination and subsequent allergic sensitization. Our findings do not support scepticism towards early childhood vaccination motivated by allergy risk. Elsevier 2018-11-06 /pmc/articles/PMC6537579/ /pubmed/31193660 http://dx.doi.org/10.1016/j.eclinm.2018.10.005 Text en © 2018 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Swartz, Jackie
Aronsson, Bernice
Lindblad, Frank
Järnbert-Pettersson, Hans
Scheynius, Annika
Pershagen, Göran
Alm, Johan
Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title_full Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title_fullStr Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title_full_unstemmed Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title_short Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort
title_sort vaccination and allergic sensitization in early childhood – the aladdin birth cohort
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537579/
https://www.ncbi.nlm.nih.gov/pubmed/31193660
http://dx.doi.org/10.1016/j.eclinm.2018.10.005
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