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The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.
The growth of telomerase-deficient cancers depends on the alternative lengthening of telomeres (ALT), a homology-directed telomere maintenance pathway. ALT telomeres exhibit a unique chromatin environment and generally lack the nucleosome remodeler ATRX, pointing to an epigenetic basis for ALT. Rece...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537592/ https://www.ncbi.nlm.nih.gov/pubmed/30833786 http://dx.doi.org/10.1038/s41594-019-0192-3 |