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Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015

The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several “superspreading” events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mut...

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Autores principales: Kim, Yeon-Sook, Aigerim, Abdimadiyeva, Park, Uni, Kim, Yuri, Rhee, Ji-Young, Choi, Jae-Phil, Park, Wan Beom, Park, Sang Won, Kim, Yeonjae, Lim, Dong-Gyun, Inn, Kyung-Soo, Hwang, Eung-Soo, Choi, Myung-Sik, Shin, Hyoung-Shik, Cho, Nam-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537729/
https://www.ncbi.nlm.nih.gov/pubmed/30900977
http://dx.doi.org/10.3201/eid2506.181722
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author Kim, Yeon-Sook
Aigerim, Abdimadiyeva
Park, Uni
Kim, Yuri
Rhee, Ji-Young
Choi, Jae-Phil
Park, Wan Beom
Park, Sang Won
Kim, Yeonjae
Lim, Dong-Gyun
Inn, Kyung-Soo
Hwang, Eung-Soo
Choi, Myung-Sik
Shin, Hyoung-Shik
Cho, Nam-Hyuk
author_facet Kim, Yeon-Sook
Aigerim, Abdimadiyeva
Park, Uni
Kim, Yuri
Rhee, Ji-Young
Choi, Jae-Phil
Park, Wan Beom
Park, Sang Won
Kim, Yeonjae
Lim, Dong-Gyun
Inn, Kyung-Soo
Hwang, Eung-Soo
Choi, Myung-Sik
Shin, Hyoung-Shik
Cho, Nam-Hyuk
author_sort Kim, Yeon-Sook
collection PubMed
description The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several “superspreading” events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.
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spelling pubmed-65377292019-06-05 Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015 Kim, Yeon-Sook Aigerim, Abdimadiyeva Park, Uni Kim, Yuri Rhee, Ji-Young Choi, Jae-Phil Park, Wan Beom Park, Sang Won Kim, Yeonjae Lim, Dong-Gyun Inn, Kyung-Soo Hwang, Eung-Soo Choi, Myung-Sik Shin, Hyoung-Shik Cho, Nam-Hyuk Emerg Infect Dis Research The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several “superspreading” events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak. Centers for Disease Control and Prevention 2019-06 /pmc/articles/PMC6537729/ /pubmed/30900977 http://dx.doi.org/10.3201/eid2506.181722 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Kim, Yeon-Sook
Aigerim, Abdimadiyeva
Park, Uni
Kim, Yuri
Rhee, Ji-Young
Choi, Jae-Phil
Park, Wan Beom
Park, Sang Won
Kim, Yeonjae
Lim, Dong-Gyun
Inn, Kyung-Soo
Hwang, Eung-Soo
Choi, Myung-Sik
Shin, Hyoung-Shik
Cho, Nam-Hyuk
Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title_full Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title_fullStr Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title_full_unstemmed Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title_short Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015
title_sort sequential emergence and wide spread of neutralization escape middle east respiratory syndrome coronavirus mutants, south korea, 2015
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537729/
https://www.ncbi.nlm.nih.gov/pubmed/30900977
http://dx.doi.org/10.3201/eid2506.181722
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