West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union

West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion-transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries a...

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Autores principales: Domanović, Dragoslav, Gossner, Celine M., Lieshout-Krikke, Ryanne, Mayr, Wolfgang, Baroti-Toth, Klara, Dobrota, Alina Mirella, Escoval, Maria Antonia, Henseler, Olaf, Jungbauer, Christof, Liumbruno, Giancarlo, Oyonarte, Salvador, Politis, Constantina, Sandid, Imad, Vidović, Miljana Stojić, Young, Johanna J., Ushiro-Lumb, Inês, Nowotny, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537739/
https://www.ncbi.nlm.nih.gov/pubmed/31107223
http://dx.doi.org/10.3201/eid2506.181755
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author Domanović, Dragoslav
Gossner, Celine M.
Lieshout-Krikke, Ryanne
Mayr, Wolfgang
Baroti-Toth, Klara
Dobrota, Alina Mirella
Escoval, Maria Antonia
Henseler, Olaf
Jungbauer, Christof
Liumbruno, Giancarlo
Oyonarte, Salvador
Politis, Constantina
Sandid, Imad
Vidović, Miljana Stojić
Young, Johanna J.
Ushiro-Lumb, Inês
Nowotny, Norbert
author_facet Domanović, Dragoslav
Gossner, Celine M.
Lieshout-Krikke, Ryanne
Mayr, Wolfgang
Baroti-Toth, Klara
Dobrota, Alina Mirella
Escoval, Maria Antonia
Henseler, Olaf
Jungbauer, Christof
Liumbruno, Giancarlo
Oyonarte, Salvador
Politis, Constantina
Sandid, Imad
Vidović, Miljana Stojić
Young, Johanna J.
Ushiro-Lumb, Inês
Nowotny, Norbert
author_sort Domanović, Dragoslav
collection PubMed
description West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion-transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries and assessed the safety of the blood supply by compiling data on WNV positivity among blood donors and on reported TT-WNV cases. The paucity of reported TT-WNV infections and the screening results suggest that blood safety interventions are effective. However, limited circulation of WNV in the EU and presumed underrecognition or underreporting of TT-WNV cases contribute to the present situation. Because of cross-reactivity between genetically related flaviviruses in the automated nucleic acid test systems, USUV-positive blood donations are found during routine WNV screening. The clinical relevance of USUV infection in humans and the risk of USUV to blood safety are unknown.
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spelling pubmed-65377392019-06-05 West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union Domanović, Dragoslav Gossner, Celine M. Lieshout-Krikke, Ryanne Mayr, Wolfgang Baroti-Toth, Klara Dobrota, Alina Mirella Escoval, Maria Antonia Henseler, Olaf Jungbauer, Christof Liumbruno, Giancarlo Oyonarte, Salvador Politis, Constantina Sandid, Imad Vidović, Miljana Stojić Young, Johanna J. Ushiro-Lumb, Inês Nowotny, Norbert Emerg Infect Dis Perspective West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion-transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries and assessed the safety of the blood supply by compiling data on WNV positivity among blood donors and on reported TT-WNV cases. The paucity of reported TT-WNV infections and the screening results suggest that blood safety interventions are effective. However, limited circulation of WNV in the EU and presumed underrecognition or underreporting of TT-WNV cases contribute to the present situation. Because of cross-reactivity between genetically related flaviviruses in the automated nucleic acid test systems, USUV-positive blood donations are found during routine WNV screening. The clinical relevance of USUV infection in humans and the risk of USUV to blood safety are unknown. Centers for Disease Control and Prevention 2019-06 /pmc/articles/PMC6537739/ /pubmed/31107223 http://dx.doi.org/10.3201/eid2506.181755 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Perspective
Domanović, Dragoslav
Gossner, Celine M.
Lieshout-Krikke, Ryanne
Mayr, Wolfgang
Baroti-Toth, Klara
Dobrota, Alina Mirella
Escoval, Maria Antonia
Henseler, Olaf
Jungbauer, Christof
Liumbruno, Giancarlo
Oyonarte, Salvador
Politis, Constantina
Sandid, Imad
Vidović, Miljana Stojić
Young, Johanna J.
Ushiro-Lumb, Inês
Nowotny, Norbert
West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title_full West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title_fullStr West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title_full_unstemmed West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title_short West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union
title_sort west nile and usutu virus infections and challenges to blood safety in the european union
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537739/
https://www.ncbi.nlm.nih.gov/pubmed/31107223
http://dx.doi.org/10.3201/eid2506.181755
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