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Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death

Patient: Male, 67 Final Diagnosis: Statin-induced rhabdomyolysis and hepatitis Symptoms: Dark urine • muscle pain • muscle weakness • pale stool • yellowish skin discoloration Medication: Atorvastatin Clinical Procedure: Dialysis Specialty: General and Internal Medicine OBJECTIVE: Unusual or unexpec...

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Autores principales: Mohamed, Mouhand F.H., Salameh, Omar K., Saeed, Abazar A.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537756/
https://www.ncbi.nlm.nih.gov/pubmed/31101801
http://dx.doi.org/10.12659/AJCR.914707
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author Mohamed, Mouhand F.H.
Salameh, Omar K.
Saeed, Abazar A.M.
author_facet Mohamed, Mouhand F.H.
Salameh, Omar K.
Saeed, Abazar A.M.
author_sort Mohamed, Mouhand F.H.
collection PubMed
description Patient: Male, 67 Final Diagnosis: Statin-induced rhabdomyolysis and hepatitis Symptoms: Dark urine • muscle pain • muscle weakness • pale stool • yellowish skin discoloration Medication: Atorvastatin Clinical Procedure: Dialysis Specialty: General and Internal Medicine OBJECTIVE: Unusual or unexpected effect of treatment BACKGROUND: Statins are effective in reducing cardiovascular morbidity and mortality, and are generally safe, but can rarely result in devastating adverse effects. With the increasing indications and prescriptions of statins, rare adverse effects are more likely to be seen and reported. Unfortunately, there are no accurate predictive tools to estimate the risk of developing these adverse effects. Post-marketing surveillance helps in collecting data on adverse effects and assists in developing better prognostic tools that can help physicians make better therapeutic decisions. CASE REPORT: A 67-year-old man was admitted to our hospital with generalized body aches, muscle weakness, jaundice, dark urine, and decreased urine output. He was started on atorvastatin 4 months prior to presentation after having an episode of myocardial infarction, and he was diagnosed as having statin-induced hepatitis, rhabdomyolysis, and acute kidney injury. A basic workup excluded other possible causes. The patient, unfortunately, died of unknown causes on day 6 after admission, and an autopsy was not performed. CONCLUSIONS: Statins are effective and safe but can result in rare and dangerous adverse effects. Physicians should counsel their patients on proper identification and timely reporting of such adverse effects. Physicians also should be encouraged to report any adverse drug reactions and help in promoting post-marketing surveillance studies. The present case is an excellent example of the importance of these studies, especially for commonly-used drugs.
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spelling pubmed-65377562019-06-12 Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death Mohamed, Mouhand F.H. Salameh, Omar K. Saeed, Abazar A.M. Am J Case Rep Articles Patient: Male, 67 Final Diagnosis: Statin-induced rhabdomyolysis and hepatitis Symptoms: Dark urine • muscle pain • muscle weakness • pale stool • yellowish skin discoloration Medication: Atorvastatin Clinical Procedure: Dialysis Specialty: General and Internal Medicine OBJECTIVE: Unusual or unexpected effect of treatment BACKGROUND: Statins are effective in reducing cardiovascular morbidity and mortality, and are generally safe, but can rarely result in devastating adverse effects. With the increasing indications and prescriptions of statins, rare adverse effects are more likely to be seen and reported. Unfortunately, there are no accurate predictive tools to estimate the risk of developing these adverse effects. Post-marketing surveillance helps in collecting data on adverse effects and assists in developing better prognostic tools that can help physicians make better therapeutic decisions. CASE REPORT: A 67-year-old man was admitted to our hospital with generalized body aches, muscle weakness, jaundice, dark urine, and decreased urine output. He was started on atorvastatin 4 months prior to presentation after having an episode of myocardial infarction, and he was diagnosed as having statin-induced hepatitis, rhabdomyolysis, and acute kidney injury. A basic workup excluded other possible causes. The patient, unfortunately, died of unknown causes on day 6 after admission, and an autopsy was not performed. CONCLUSIONS: Statins are effective and safe but can result in rare and dangerous adverse effects. Physicians should counsel their patients on proper identification and timely reporting of such adverse effects. Physicians also should be encouraged to report any adverse drug reactions and help in promoting post-marketing surveillance studies. The present case is an excellent example of the importance of these studies, especially for commonly-used drugs. International Scientific Literature, Inc. 2019-05-18 /pmc/articles/PMC6537756/ /pubmed/31101801 http://dx.doi.org/10.12659/AJCR.914707 Text en © Am J Case Rep, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Mohamed, Mouhand F.H.
Salameh, Omar K.
Saeed, Abazar A.M.
Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title_full Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title_fullStr Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title_full_unstemmed Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title_short Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death
title_sort statin-induced rhabdomyolysis, acute kidney injury, and hepatitis leading to death
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537756/
https://www.ncbi.nlm.nih.gov/pubmed/31101801
http://dx.doi.org/10.12659/AJCR.914707
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