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Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans
BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate. OBJECTIVE: We evaluated the impact of consuming IT...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537941/ https://www.ncbi.nlm.nih.gov/pubmed/31108510 http://dx.doi.org/10.1093/ajcn/nqz001 |
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author | Hiel, Sophie Bindels, Laure B Pachikian, Barbara D Kalala, Gaetan Broers, Valérie Zamariola, Giorgia Chang, Betty P I Kambashi, Bienvenu Rodriguez, Julie Cani, Patrice D Neyrinck, Audrey M Thissen, Jean-Paul Luminet, Olivier Bindelle, Jérôme Delzenne, Nathalie M |
author_facet | Hiel, Sophie Bindels, Laure B Pachikian, Barbara D Kalala, Gaetan Broers, Valérie Zamariola, Giorgia Chang, Betty P I Kambashi, Bienvenu Rodriguez, Julie Cani, Patrice D Neyrinck, Audrey M Thissen, Jean-Paul Luminet, Olivier Bindelle, Jérôme Delzenne, Nathalie M |
author_sort | Hiel, Sophie |
collection | PubMed |
description | BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate. OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals. METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms. RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention. CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550. |
format | Online Article Text |
id | pubmed-6537941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-65379412019-05-30 Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans Hiel, Sophie Bindels, Laure B Pachikian, Barbara D Kalala, Gaetan Broers, Valérie Zamariola, Giorgia Chang, Betty P I Kambashi, Bienvenu Rodriguez, Julie Cani, Patrice D Neyrinck, Audrey M Thissen, Jean-Paul Luminet, Olivier Bindelle, Jérôme Delzenne, Nathalie M Am J Clin Nutr Original Research Communications BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate. OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals. METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms. RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention. CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550. Oxford University Press 2019-06 2019-04-24 /pmc/articles/PMC6537941/ /pubmed/31108510 http://dx.doi.org/10.1093/ajcn/nqz001 Text en Copyright © American Society for Nutrition 2019. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Research Communications Hiel, Sophie Bindels, Laure B Pachikian, Barbara D Kalala, Gaetan Broers, Valérie Zamariola, Giorgia Chang, Betty P I Kambashi, Bienvenu Rodriguez, Julie Cani, Patrice D Neyrinck, Audrey M Thissen, Jean-Paul Luminet, Olivier Bindelle, Jérôme Delzenne, Nathalie M Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title | Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title_full | Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title_fullStr | Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title_full_unstemmed | Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title_short | Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
title_sort | effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans |
topic | Original Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537941/ https://www.ncbi.nlm.nih.gov/pubmed/31108510 http://dx.doi.org/10.1093/ajcn/nqz001 |
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