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FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania

PURPOSE: Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns’ risk of NCDs may provide approaches to prevent NCD...

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Autores principales: Hjort, Line, Lykke Møller, Sofie, Minja, Daniel, Msemo, Omari, Nielsen, Birgitte Bruun, Lund Christensen, Dirk, Theander, Thor, Nielsen, Karsten, Larsen, Lise Grupe, Grunnet, Louise Groth, Groop, Leif, Prasad, Rashmi, Lusingu, John, Schmiegelow, Christentze, Bygbjerg, Ib C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537995/
https://www.ncbi.nlm.nih.gov/pubmed/31122967
http://dx.doi.org/10.1136/bmjopen-2018-024861
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author Hjort, Line
Lykke Møller, Sofie
Minja, Daniel
Msemo, Omari
Nielsen, Birgitte Bruun
Lund Christensen, Dirk
Theander, Thor
Nielsen, Karsten
Larsen, Lise Grupe
Grunnet, Louise Groth
Groop, Leif
Prasad, Rashmi
Lusingu, John
Schmiegelow, Christentze
Bygbjerg, Ib C
author_facet Hjort, Line
Lykke Møller, Sofie
Minja, Daniel
Msemo, Omari
Nielsen, Birgitte Bruun
Lund Christensen, Dirk
Theander, Thor
Nielsen, Karsten
Larsen, Lise Grupe
Grunnet, Louise Groth
Groop, Leif
Prasad, Rashmi
Lusingu, John
Schmiegelow, Christentze
Bygbjerg, Ib C
author_sort Hjort, Line
collection PubMed
description PURPOSE: Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns’ risk of NCDs may provide approaches to prevent NCDs. PARTICIPANTS: The FOETALforNCD (FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life) Study is a population-based preconception, pregnancy and birth cohort study (n=1415, n=538, n=427, respectively), conducted in a rural region of North-East Tanzania. All participants were recruited prior to conception or early in pregnancy and followed throughout pregnancy as well as at birth. Data collection included: maternal blood, screening for NCDs and malaria, ultrasound in each trimester, neonatal anthropometry at birth and at 1 month of age, cord blood, placental and cord biopsies for stereology and epigenetic analyses. FINDINGS TO DATE: At preconception, the average age, body mass index and blood pressure of the women were 28 years, 23 kg/m(2) and 117/75 mm Hg, respectively. In total, 458 (36.7%) women had anaemia (haemoglobin Hb <12 g/dL) and 34 (3.6%) women were HIV-positive at preconception. During pregnancy 359 (66.7%) women had anaemia of which 85 (15.8%) women had moderate-to-severe anaemia (Hb ≤9 g/dL) and 33 (6.1%) women had severe anaemia (Hb ≤8 g/dL). In total, 185 (34.4%) women were diagnosed with malaria during pregnancy. FUTURE PLANS: The project will provide new knowledge on how health, even before conception, might modify the risk of developing NCDs and how to promote better health during pregnancy. The present project ended data collection 1 month after giving birth, but follow-up is continuing through regular monitoring of growth and development and health events according to the National Road Map Strategic Plan in Tanzania. This data will link fetal adverse event to childhood development, and depending on further grant allocation, through a life course follow-up.
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spelling pubmed-65379952019-06-12 FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania Hjort, Line Lykke Møller, Sofie Minja, Daniel Msemo, Omari Nielsen, Birgitte Bruun Lund Christensen, Dirk Theander, Thor Nielsen, Karsten Larsen, Lise Grupe Grunnet, Louise Groth Groop, Leif Prasad, Rashmi Lusingu, John Schmiegelow, Christentze Bygbjerg, Ib C BMJ Open Global Health PURPOSE: Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns’ risk of NCDs may provide approaches to prevent NCDs. PARTICIPANTS: The FOETALforNCD (FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life) Study is a population-based preconception, pregnancy and birth cohort study (n=1415, n=538, n=427, respectively), conducted in a rural region of North-East Tanzania. All participants were recruited prior to conception or early in pregnancy and followed throughout pregnancy as well as at birth. Data collection included: maternal blood, screening for NCDs and malaria, ultrasound in each trimester, neonatal anthropometry at birth and at 1 month of age, cord blood, placental and cord biopsies for stereology and epigenetic analyses. FINDINGS TO DATE: At preconception, the average age, body mass index and blood pressure of the women were 28 years, 23 kg/m(2) and 117/75 mm Hg, respectively. In total, 458 (36.7%) women had anaemia (haemoglobin Hb <12 g/dL) and 34 (3.6%) women were HIV-positive at preconception. During pregnancy 359 (66.7%) women had anaemia of which 85 (15.8%) women had moderate-to-severe anaemia (Hb ≤9 g/dL) and 33 (6.1%) women had severe anaemia (Hb ≤8 g/dL). In total, 185 (34.4%) women were diagnosed with malaria during pregnancy. FUTURE PLANS: The project will provide new knowledge on how health, even before conception, might modify the risk of developing NCDs and how to promote better health during pregnancy. The present project ended data collection 1 month after giving birth, but follow-up is continuing through regular monitoring of growth and development and health events according to the National Road Map Strategic Plan in Tanzania. This data will link fetal adverse event to childhood development, and depending on further grant allocation, through a life course follow-up. BMJ Publishing Group 2019-05-22 /pmc/articles/PMC6537995/ /pubmed/31122967 http://dx.doi.org/10.1136/bmjopen-2018-024861 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Global Health
Hjort, Line
Lykke Møller, Sofie
Minja, Daniel
Msemo, Omari
Nielsen, Birgitte Bruun
Lund Christensen, Dirk
Theander, Thor
Nielsen, Karsten
Larsen, Lise Grupe
Grunnet, Louise Groth
Groop, Leif
Prasad, Rashmi
Lusingu, John
Schmiegelow, Christentze
Bygbjerg, Ib C
FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title_full FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title_fullStr FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title_full_unstemmed FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title_short FOETAL for NCD—FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania
title_sort foetal for ncd—foetal exposure and epidemiological transitions: the role of anaemia in early life for non-communicable diseases in later life: a prospective preconception study in rural tanzania
topic Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537995/
https://www.ncbi.nlm.nih.gov/pubmed/31122967
http://dx.doi.org/10.1136/bmjopen-2018-024861
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