A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib

Sunitinib is an oral tyrosine kinase inhibitor (TKI) commonly used in the treatment of renal cell carcinoma (RCC). Among a broad range of toxicities, anemia and macrocytosis are common in patients treated with sunitinib. Correlation between sunitinib-associated macrocytosis and cobalamin deficiency...

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Detalles Bibliográficos
Autores principales: Reed, Jarred P, Chung, Joan, Banerjee, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Urology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538120/
https://www.ncbi.nlm.nih.gov/pubmed/31183290
http://dx.doi.org/10.7759/cureus.4310
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author Reed, Jarred P
Chung, Joan
Banerjee, Natasha
author_facet Reed, Jarred P
Chung, Joan
Banerjee, Natasha
author_sort Reed, Jarred P
collection PubMed
description Sunitinib is an oral tyrosine kinase inhibitor (TKI) commonly used in the treatment of renal cell carcinoma (RCC). Among a broad range of toxicities, anemia and macrocytosis are common in patients treated with sunitinib. Correlation between sunitinib-associated macrocytosis and cobalamin deficiency has been reported in small case series and retrospective analyses, although others have not found an association. Here, we present a case of transfusion-dependent macrocytic anemia with cobalamin and folate deficiency in a patient with RCC treated with sunitinib.
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spelling pubmed-65381202019-06-10 A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib Reed, Jarred P Chung, Joan Banerjee, Natasha Cureus Urology Sunitinib is an oral tyrosine kinase inhibitor (TKI) commonly used in the treatment of renal cell carcinoma (RCC). Among a broad range of toxicities, anemia and macrocytosis are common in patients treated with sunitinib. Correlation between sunitinib-associated macrocytosis and cobalamin deficiency has been reported in small case series and retrospective analyses, although others have not found an association. Here, we present a case of transfusion-dependent macrocytic anemia with cobalamin and folate deficiency in a patient with RCC treated with sunitinib. Cureus 2019-03-25 /pmc/articles/PMC6538120/ /pubmed/31183290 http://dx.doi.org/10.7759/cureus.4310 Text en Copyright © 2019, Reed et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Reed, Jarred P
Chung, Joan
Banerjee, Natasha
A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title_full A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title_fullStr A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title_full_unstemmed A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title_short A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib
title_sort case of cobalamin deficiency and macrocytic anemia secondary to sunitinib
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538120/
https://www.ncbi.nlm.nih.gov/pubmed/31183290
http://dx.doi.org/10.7759/cureus.4310
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