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Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol

INTRODUCTION: One-quarter of the global population, including the majority of adults in tuberculosis (TB) endemic countries, are estimated to be Mycobacterium tuberculosis (MTB) infected. An estimated 10 million new TB cases occurred in 2017. One of the biggest challenges confronting TB control is t...

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Autores principales: Mulenga, Humphrey, Bunyasi, Erick Wekesa, Mbandi, Stanley Kimbung, Mendelsohn, Simon C, Kagina, Benjamin, Penn-Nicholson, Adam, Scriba, Thomas, Hatherill, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538208/
https://www.ncbi.nlm.nih.gov/pubmed/31122978
http://dx.doi.org/10.1136/bmjopen-2018-026612
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author Mulenga, Humphrey
Bunyasi, Erick Wekesa
Mbandi, Stanley Kimbung
Mendelsohn, Simon C
Kagina, Benjamin
Penn-Nicholson, Adam
Scriba, Thomas
Hatherill, Mark
author_facet Mulenga, Humphrey
Bunyasi, Erick Wekesa
Mbandi, Stanley Kimbung
Mendelsohn, Simon C
Kagina, Benjamin
Penn-Nicholson, Adam
Scriba, Thomas
Hatherill, Mark
author_sort Mulenga, Humphrey
collection PubMed
description INTRODUCTION: One-quarter of the global population, including the majority of adults in tuberculosis (TB) endemic countries, are estimated to be Mycobacterium tuberculosis (MTB) infected. An estimated 10 million new TB cases occurred in 2017. One of the biggest challenges confronting TB control is the lack of accurate diagnosis and prediction of prevalent and incident TB disease, respectively. Several host blood transcriptomic messenger RNA (mRNA) signatures that reflect the host immune response following infection with MTB and progression to TB disease in different study populations have recently been published, but these TB biomarkers have not been systematically described. We will conduct a systematic review of the performance of host blood transcriptional signatures for TB diagnosis and prediction of progression to TB disease. METHODS AND ANALYSIS: This systematic review will involve conducting a comprehensive literature search of cohort, case–control, cross-sectional and randomised-controlled studies of the performance of host blood transcriptomic signatures for TB diagnosis and prediction of progression to TB disease. We will search Medline via PubMed, Scopus, Web of Science and EBSCO libraries, complemented by a search of bibliographies of selected articles for other relevant articles. The literature search will be restricted to studies published in English from 2005 to 2018 and conducted in HIV-uninfected adults and adolescents (≥12 years old). Forest plots and a narrative synthesis of the findings will be provided. The primary outcomes will be sensitivity, specificity, as well as true/false positives and true/false negatives. Heterogeneity resulting from differences in the design, composition and structure of individual signatures will preclude meta-analysis and pooling of results. ETHICS AND DISSEMINATION: Ethics approval is not required for this systematic review protocol. The results of this review will be disseminated through a peer-reviewed journal as well as conference presentations. PROSPERO REGISTRATION NUMBER: CRD42017073817.
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spelling pubmed-65382082019-06-12 Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol Mulenga, Humphrey Bunyasi, Erick Wekesa Mbandi, Stanley Kimbung Mendelsohn, Simon C Kagina, Benjamin Penn-Nicholson, Adam Scriba, Thomas Hatherill, Mark BMJ Open Public Health INTRODUCTION: One-quarter of the global population, including the majority of adults in tuberculosis (TB) endemic countries, are estimated to be Mycobacterium tuberculosis (MTB) infected. An estimated 10 million new TB cases occurred in 2017. One of the biggest challenges confronting TB control is the lack of accurate diagnosis and prediction of prevalent and incident TB disease, respectively. Several host blood transcriptomic messenger RNA (mRNA) signatures that reflect the host immune response following infection with MTB and progression to TB disease in different study populations have recently been published, but these TB biomarkers have not been systematically described. We will conduct a systematic review of the performance of host blood transcriptional signatures for TB diagnosis and prediction of progression to TB disease. METHODS AND ANALYSIS: This systematic review will involve conducting a comprehensive literature search of cohort, case–control, cross-sectional and randomised-controlled studies of the performance of host blood transcriptomic signatures for TB diagnosis and prediction of progression to TB disease. We will search Medline via PubMed, Scopus, Web of Science and EBSCO libraries, complemented by a search of bibliographies of selected articles for other relevant articles. The literature search will be restricted to studies published in English from 2005 to 2018 and conducted in HIV-uninfected adults and adolescents (≥12 years old). Forest plots and a narrative synthesis of the findings will be provided. The primary outcomes will be sensitivity, specificity, as well as true/false positives and true/false negatives. Heterogeneity resulting from differences in the design, composition and structure of individual signatures will preclude meta-analysis and pooling of results. ETHICS AND DISSEMINATION: Ethics approval is not required for this systematic review protocol. The results of this review will be disseminated through a peer-reviewed journal as well as conference presentations. PROSPERO REGISTRATION NUMBER: CRD42017073817. BMJ Publishing Group 2019-05-22 /pmc/articles/PMC6538208/ /pubmed/31122978 http://dx.doi.org/10.1136/bmjopen-2018-026612 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Public Health
Mulenga, Humphrey
Bunyasi, Erick Wekesa
Mbandi, Stanley Kimbung
Mendelsohn, Simon C
Kagina, Benjamin
Penn-Nicholson, Adam
Scriba, Thomas
Hatherill, Mark
Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title_full Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title_fullStr Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title_full_unstemmed Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title_short Performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in HIV-negative adults and adolescents: a systematic review protocol
title_sort performance of host blood transcriptomic signatures for diagnosing and predicting progression to tuberculosis disease in hiv-negative adults and adolescents: a systematic review protocol
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538208/
https://www.ncbi.nlm.nih.gov/pubmed/31122978
http://dx.doi.org/10.1136/bmjopen-2018-026612
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