TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

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Because injured mitochondria can accelerate cell death through the elaboration of oxidative free radicals and other mediators, it is striking that proliferator γ coactivator 1-α (PGC1α), a stimulator of increased mitochondrial abundance, protects stressed renal cells instead of potentiating injury....

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Detalles Bibliográficos
Autores principales: Lynch, Matthew R., Tran, Mei T., Ralto, Kenneth M., Zsengeller, Zsuzsanna K., Raman, Vinod, Bhasin, Swati S., Sun, Nuo, Chen, Xiuying, Brown, Daniel, Rovira, Ilsa I., Taguchi, Kensei, Brooks, Craig R., Stillman, Isaac E., Bhasin, Manoj K., Finkel, Toren, Parikh, Samir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538327/
https://www.ncbi.nlm.nih.gov/pubmed/30870143
http://dx.doi.org/10.1172/jci.insight.126749
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