Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy

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Sarcomeric disarray is a hallmark of gene mutations in patients with hypertrophic cardiomyopathy (HCM). However, it is unknown when detrimental sarcomeric changes first occur and whether they originate in the developing embryonic heart. Furthermore, Rho kinase (ROCK) is a serine/threonine protein ki...

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Detalles Bibliográficos
Autores principales: Bailey, Kate E., MacGowan, Guy A., Tual-Chalot, Simon, Phillips, Lauren, Mohun, Timothy J., Henderson, Deborah J., Arthur, Helen M., Bamforth, Simon D., Phillips, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538384/
https://www.ncbi.nlm.nih.gov/pubmed/30835717
http://dx.doi.org/10.1172/jci.insight.125172
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