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RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its defic...

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Autores principales: Yu, Hong-En, Wang, Feng, Yu, Fang, Zeng, Zhao-Lei, Wang, Yun, Lu, Yun-Xin, Jin, Ying, Wang, De-Shen, Qiu, Miao-Zhen, Pu, Heng-Ying, Kang, Tie-Bang, Xie, Dan, Ju, Huai-Qiang, Xu, Rui-Hua, Luo, Hui-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538639/
https://www.ncbi.nlm.nih.gov/pubmed/31138787
http://dx.doi.org/10.1038/s41419-019-1652-8
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author Yu, Hong-En
Wang, Feng
Yu, Fang
Zeng, Zhao-Lei
Wang, Yun
Lu, Yun-Xin
Jin, Ying
Wang, De-Shen
Qiu, Miao-Zhen
Pu, Heng-Ying
Kang, Tie-Bang
Xie, Dan
Ju, Huai-Qiang
Xu, Rui-Hua
Luo, Hui-Yan
author_facet Yu, Hong-En
Wang, Feng
Yu, Fang
Zeng, Zhao-Lei
Wang, Yun
Lu, Yun-Xin
Jin, Ying
Wang, De-Shen
Qiu, Miao-Zhen
Pu, Heng-Ying
Kang, Tie-Bang
Xie, Dan
Ju, Huai-Qiang
Xu, Rui-Hua
Luo, Hui-Yan
author_sort Yu, Hong-En
collection PubMed
description Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy.
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spelling pubmed-65386392019-05-29 RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer Yu, Hong-En Wang, Feng Yu, Fang Zeng, Zhao-Lei Wang, Yun Lu, Yun-Xin Jin, Ying Wang, De-Shen Qiu, Miao-Zhen Pu, Heng-Ying Kang, Tie-Bang Xie, Dan Ju, Huai-Qiang Xu, Rui-Hua Luo, Hui-Yan Cell Death Dis Article Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy. Nature Publishing Group UK 2019-05-28 /pmc/articles/PMC6538639/ /pubmed/31138787 http://dx.doi.org/10.1038/s41419-019-1652-8 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yu, Hong-En
Wang, Feng
Yu, Fang
Zeng, Zhao-Lei
Wang, Yun
Lu, Yun-Xin
Jin, Ying
Wang, De-Shen
Qiu, Miao-Zhen
Pu, Heng-Ying
Kang, Tie-Bang
Xie, Dan
Ju, Huai-Qiang
Xu, Rui-Hua
Luo, Hui-Yan
RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title_full RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title_fullStr RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title_full_unstemmed RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title_short RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
title_sort retracted article: suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538639/
https://www.ncbi.nlm.nih.gov/pubmed/31138787
http://dx.doi.org/10.1038/s41419-019-1652-8
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