Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling mechanisms that mediate these effects remain ill-defined. Here we show that CARD11-BCL10-MALT1 (CBM)...

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Detalles Bibliográficos
Autores principales: Rosenbaum, Marc, Gewies, Andreas, Pechloff, Konstanze, Heuser, Christoph, Engleitner, Thomas, Gehring, Torben, Hartjes, Lara, Krebs, Sabrina, Krappmann, Daniel, Kriegsmann, Mark, Weichert, Wilko, Rad, Roland, Kurts, Christian, Ruland, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538646/
https://www.ncbi.nlm.nih.gov/pubmed/31138793
http://dx.doi.org/10.1038/s41467-019-10203-2

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