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Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level

Trifluridine (FTD), a tri-fluorinated thymidine analogue, is a key component of the oral antitumor drug FTD/TPI (also known as TAS-102), which is used to treat refractory metastatic colorectal cancer. Thymidine kinase 1 (TK1) is thought to be important for the incorporation of FTD into DNA, resultin...

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Detalles Bibliográficos
Autores principales:	Kataoka, Yuki, Iimori, Makoto, Niimi, Shinichiro, Tsukihara, Hiroshi, Wakasa, Takeshi, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko, Kitao, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538667/ https://www.ncbi.nlm.nih.gov/pubmed/31138881 http://dx.doi.org/10.1038/s41598-019-44399-6

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