Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (1–4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by s...

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Detalles Bibliográficos
Autores principales: Xu, Hou-Chao, Hu, Kun, Sun, Han-Dong, Puno, Pema-Tenzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538734/
https://www.ncbi.nlm.nih.gov/pubmed/30977051
http://dx.doi.org/10.1007/s13659-019-0203-4
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author Xu, Hou-Chao
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
author_facet Xu, Hou-Chao
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
author_sort Xu, Hou-Chao
collection PubMed
description Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (1–4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-0203-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-65387342019-06-12 Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea Xu, Hou-Chao Hu, Kun Sun, Han-Dong Puno, Pema-Tenzin Nat Prod Bioprospect Original Article Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (1–4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-0203-4) contains supplementary material, which is available to authorized users. Springer Singapore 2019-04-11 /pmc/articles/PMC6538734/ /pubmed/30977051 http://dx.doi.org/10.1007/s13659-019-0203-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Xu, Hou-Chao
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title_full Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title_fullStr Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title_full_unstemmed Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title_short Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
title_sort four 14(13 → 12)-abeolanostane triterpenoids with 6/6/5/6-fused ring system from the roots of kadsura coccinea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538734/
https://www.ncbi.nlm.nih.gov/pubmed/30977051
http://dx.doi.org/10.1007/s13659-019-0203-4
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