Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum

ABSTRACT: Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjecte...

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Autores principales: Yu, Hai-Li, Long, Qin, Yi, Wen-Fang, Yang, Bao-Jia, Song, Yu, Ding, Xiao, Li, Shun-Lin, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538742/
https://www.ncbi.nlm.nih.gov/pubmed/31028545
http://dx.doi.org/10.1007/s13659-019-0205-2
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author Yu, Hai-Li
Long, Qin
Yi, Wen-Fang
Yang, Bao-Jia
Song, Yu
Ding, Xiao
Li, Shun-Lin
Hao, Xiao-Jiang
author_facet Yu, Hai-Li
Long, Qin
Yi, Wen-Fang
Yang, Bao-Jia
Song, Yu
Ding, Xiao
Li, Shun-Lin
Hao, Xiao-Jiang
author_sort Yu, Hai-Li
collection PubMed
description ABSTRACT: Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-65387422019-06-12 Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum Yu, Hai-Li Long, Qin Yi, Wen-Fang Yang, Bao-Jia Song, Yu Ding, Xiao Li, Shun-Lin Hao, Xiao-Jiang Nat Prod Bioprospect Original Article ABSTRACT: Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability. GRAPHICAL ABSTRACT: [Image: see text] Springer Singapore 2019-04-26 /pmc/articles/PMC6538742/ /pubmed/31028545 http://dx.doi.org/10.1007/s13659-019-0205-2 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Yu, Hai-Li
Long, Qin
Yi, Wen-Fang
Yang, Bao-Jia
Song, Yu
Ding, Xiao
Li, Shun-Lin
Hao, Xiao-Jiang
Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title_full Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title_fullStr Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title_full_unstemmed Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title_short Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum
title_sort two new c21 steroidal glycosides from the roots of cynanchum paniculatum
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538742/
https://www.ncbi.nlm.nih.gov/pubmed/31028545
http://dx.doi.org/10.1007/s13659-019-0205-2
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