Cargando…

Cochlea-Specific Deletion of Ca(v)1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Inner hair cell (IHC) Ca(v)1.3 Ca(2+) channels are multifunctional channels mediating Ca(2+) influx for exocytosis at ribbon synapses, the generation of Ca(2+) action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Ca(v)1.3-deficient (Ca(v)1.3(-/-)) mice stay immature becau...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eckrich, Stephanie, Hecker, Dietmar, Sorg, Katharina, Blum, Kerstin, Fischer, Kerstin, Münkner, Stefan, Wenzel, Gentiana, Schick, Bernhard, Engel, Jutta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538774/ https://www.ncbi.nlm.nih.gov/pubmed/31178698 http://dx.doi.org/10.3389/fncel.2019.00225

Ejemplares similares

Fast Ca(2+) Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca(2+) Waves of Inner Supporting Cells in the Developing Mouse Cochlea
por: Eckrich, Tobias, et al.
Publicado: (2018)

Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets
por: Sonntag, Mandy, et al.
Publicado: (2018)

Elementary properties of Ca(V)1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells
por: Zampini, Valeria, et al.
Publicado: (2010)

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
por: Jean, Philippe, et al.
Publicado: (2020)

MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea
por: Ikäheimo, Kuu, et al.
Publicado: (2021)

Deletion of the Ca(2+) Channel Subunit α(2)δ3 Differentially Affects Ca(v)2.1 and Ca(v)2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing
por: Stephani, Friederike, et al.
Publicado: (2019)

Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ—A Novel CT-Guided Approach to the Cochlea
por: Englisch, Colya N., et al.
Publicado: (2023)

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea
por: Bardhan, Tanaya, et al.
Publicado: (2019)

Hidden hearing loss is associated with loss of ribbon synapses of cochlea inner hair cells
por: Song, Feng, et al.
Publicado: (2021)

Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells
por: Heuermann, Mitchell L., et al.
Publicado: (2022)

Cytotoxicity studies of an optoacoustic stimulation strategy for the development of laser-based hearing aids
por: Pillong, Lukas, et al.
Publicado: (2020)

Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
por: Sawamura, Seishiro, et al.
Publicado: (2021)

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression
por: Liu, Zhiyong, et al.
Publicado: (2014)

Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea
por: Johnson, Stuart L., et al.
Publicado: (2017)

RBP2 stabilizes slow Cav1.3 Ca(2+) channel inactivation properties of cochlear inner hair cells
por: Ortner, Nadine J., et al.
Publicado: (2019)

Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea
por: Jin, Yecheng, et al.
Publicado: (2016)

Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea
por: Xu, Changling, et al.
Publicado: (2023)

Wavelength-specific optoacoustic-induced vibrations of the guinea pig tympanic membrane
por: Heimann, Larissa, et al.
Publicado: (2021)

Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film
por: Sorg, Katharina, et al.
Publicado: (2021)

Temperature Enhances Activation and Inactivation Kinetics of Potassium Currents in Inner Hair Cells Isolated from Guinea-Pig Cochlea
por: Kimitsuki, Takashi, et al.
Publicado: (2013)

Regulation of Ca(V)1.3 Ca(2+) channels in cochlear inner hair cells
por: Pinggera, Alexandra, et al.
Publicado: (2012)

Actin filaments, stereocilia, and hair cells of the bird cochlea. I. Length, number, width, and distribution of stereocilia of each hair cell are related to the position of the hair cell on the cochlea
Publicado: (1983)

Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering
por: Mellott, Adam J., et al.
Publicado: (2017)

First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model
por: Sorg, Katharina, et al.
Publicado: (2019)

Renewed proliferation in adult mouse cochlea and regeneration of hair cells
por: Shu, Yilai, et al.
Publicado: (2019)

Gene therapy: an emerging therapy for hair cells regeneration in the cochlea
por: Wang, Jipeng, et al.
Publicado: (2023)

Defining the Inflammatory Microenvironment in the Human Cochlea by Perilymph Analysis: Toward Liquid Biopsy of the Cochlea
por: Warnecke, Athanasia, et al.
Publicado: (2019)

Neural Crest Stem Cells in Juvenile Angiofibromas
por: Schick, Bernhard, et al.
Publicado: (2022)

A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue
por: Boyadzhieva, Silviya, et al.
Publicado: (2019)

Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
por: Eckrich, Tobias, et al.
Publicado: (2012)

Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
por: Durán Alonso, María Beatriz, et al.
Publicado: (2021)

Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
por: Johnson, Stuart L., et al.
Publicado: (2011)

Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear
por: Bellos, Christos, et al.
Publicado: (2014)

Neurod1 Suppresses Hair Cell Differentiation in Ear Ganglia and Regulates Hair Cell Subtype Development in the Cochlea
por: Jahan, Israt, et al.
Publicado: (2010)

The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification
por: Buswinka, Christopher J., et al.
Publicado: (2023)

Fine Tuning of Ca(V)1.3 Ca(2+) Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea
por: Zampini, Valeria, et al.
Publicado: (2014)

Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea
Publicado: (1989)

In Vivo Outer Hair Cell Length Changes Expose the Active Process in the Cochlea
por: Zha, Dingjun, et al.
Publicado: (2012)

Evaluation of Hearing and Outer Hair Cell Function of Cochlea in Patients With Psoriatic Arthritis
por: Akdag, Mehmet, et al.
Publicado: (2015)

Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
por: Lee, Sungsu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7puvmi01g9aetj6njqgcj53td4